1. Model the development of tumor formation with organoid culture, study the interplay between tumor-driver mutations.
  2. Use single cell sequencing techniques to study tumor heterogeneity and to identify key transcription factors that drive different tumor phenotypes.
  3. Use CRISPR-based genetic screen to discover key regulatory elements of cellular phenotype and cell signaling pathway.
  4. Develop novel methods associated with pooled CRISPR screen and single cell sequencing.

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