Professor Guozhi Xiao is an internationally renowned bone biologist. Dr. Xiao obtained his PhD degree in biochemistry and molecular biology from Peking University in 1994. He finished his post-doc training (1994-1998) and worked as a research scientist (1998-2005) at the University of Michigan Ann Arbor. In 2005, he assumed an independent faculty position as a tenure-track assistant professor at the University of Pittsburgh School of Medicine in 2005 and was promoted to the level of associate professor with tenure in 2011. In 2012, he joined Rush University Medical Center in Chicago and assumed a prominent academic position as the Falk Endowed Chair Professor of Biochemistry and served as the director of research of the department of biochemistry. He later joined the SUSTech as a tenured full professor and later became the chair of the biological department. Dr. Xiao is the director of the Center for Experimental Animals at SUSTech. Dr. Xiao has made several contributions to our understanding the molecular control of skeletal development and homeostasis. His work is reported in 155 SCI-indexed articles, many in high profile journals, such as Nature Aging, Journal of Clinical Investigation and Nature Communications etc., and 16 book chapters etc. He serves as a reviewer for the US National Science Foundation, the Italian Ministry of Health and the National Natural Science Foundation of China and sits on the editorial boards of the Journal of Bone and Mineral Research (JBMR) and the Journal of Biological Chemistry (JBC). Dr. Xiao’s research interests focus in the following areas: (1) to determine how osteoblast, osteoclast, and chondrocyte formation is controlled during skeletal development and homeostasis under physiological and pathological conditions; (2) to define the mechanisms that modulate bone angiogenesis; and more recently; (3) to study the roles of focal adhesion (FA) proteins in skeletal development and homeostasis. By working on these projects, Xiao laboratory has also maintained a focus on important medical issues involving bone –osteoarthritis, osteoporosis, and disc degeneration. Information obtained from these studies will enhance our understanding of these pathological processes.