副教授 |生命科学学院, 生物系
吴柘,2005年本科毕业于青岛大学。2011年博士毕业于北京大学生物技术专业,师从瞿礼嘉教授及顾红雅教授。2011-2016年在英国约翰英纳斯中心,任博士后及高级博士后研究员,师从Caroline Dean院士。2016年11月-2022年11月在南方科技大学生物系任助理教授,2022年12月起任长聘副教授。作为通讯作者在Nature Genetics, Genome Biology, Plant Cell, Molecular Plant, New Phytologist, Plant Methods等主流期刊上发表论文多篇。现任Essays in Biochemistry 期刊编委。
吴柘实验室主要关注植物生殖相关(开花,配子形成,种子发育、成熟及萌发)的分子调控机理,重点探究RNA-蛋白在转录同时的包装过程以及表观遗传调控在其中所发挥的作用及机制。在方法上,我们采用遗传学及前沿的表观组学技术为研究的主要手段,结合重要的生物学过程,我们希望即见树木(单个重要的基因)又见森林(在基因组范围内的普遍模式和规律),揭示植物发育及基因表达调控背后的普遍规律。
个人简介
个人简介:
吴柘,2005年本科毕业于青岛大学。2011年博士毕业于北京大学生物技术专业,师从瞿礼嘉教授及顾红雅教授。2011-2016年在英国约翰英纳斯中心,任博士后及高级博士后研究员,师从Caroline Dean院士。2016年12月起入职南方科技大学生物系任助理教授。过去五年第一作者(含并列)身份在PNAS, Plant Cell, Cell Systems及Molecular Plant等国际主流期刊上发表论文5篇。吴柘实验室主要以植物为模式,研究RNA结合蛋白的分子功能,探究这类蛋白所介导的分子事件在植物发育及植物-环境互作过程中的作用机制。生物学事件上关注开花,种子萌发,配子体发育等一系列具有重大农艺及基础研究价值的发育过程。关注RNA结合蛋白所介导的转录及转录后调控机制在这些生物学过程中所发挥的作用。
研究领域:
1 RNA结合蛋白在植物发育及环境响应中的作用机制
2转录同时发生的RNA命运决定机制。
3组蛋白变体及组蛋白分子伴侣对植物基因转录及细胞分化的调控。
所获荣誉:
2008年,国家建设高水平大学公派研究生
2017年,孔雀计划C类
2017年,广东省创业创新团队,海外青年团队-核心成员
学术服务:
Essays in Biochemistry编委
科研项目:
2018年,国自然面上项目,60万,主持
2020年,国自然面上项目,58万,主持
代表著作
*表示第一作者及共同第一作者
- Wu Z., Fang X., Zhu D., Dean C. Autonomous pathway: FLC repression through an antisense-mediated chromatin silencing mechanism. Plant Physiology
- Huang J., Gu L. Zhang Y., Yan T., Kong G., Kong L., Guo B., Qiu M., Wang Y., Jing M., Xing W., Ye W., Wu Z., Zhang Z., Zheng X., Gijzen M., Wang Y., Dong S. (2017). An oomycete plant pathogen reprograms host pre-mRNA splicing to subvert immunity. Nature Communications 8, 2051-2063.
- Ietswaart, R.*, Rosa, S.*, Wu, Z.*, Dean, C., and Howard, M. (2017). Cell-size-dependent transcription of FLC and its antisense long non-coding RNA COOLAIR explain cell-to-cell expression variation. Cell Systems 4, 622-635 e629.
- Wu,*, Ietswaart, R.*, Liu, F., Yang, H., Howard, M., and Dean, C. (2016). Quantitativeregulation of FLC via coordinated transcriptional initiation and elongation. PNAS 113,218-223.
- Wu, Z.*, Zhu, D.*, Lin, X.*, Miao, J.*, Gu, L., Deng, X., Yang, Q., Sun, K., Cao, X., Tsuge, T., Dean, C., Aoyama, T., Gu, H., and Qu, L.J. (2016). RNA-binding proteins RZ-1B andRZ-1C play critical roles in regulating pre-mRNA splicing and gene expression duringdevelopment in Arabidopsis. The Plant Cell 28, 55-73.
- Wang, Z.W.*, Wu, Z.*, Raitskin, O., Sun, Q., and Dean, C. (2014). Antisense-mediated FLCtranscriptional repression requires the P-TEFb transcription elongation factor. PNAS 111,7468-7473.
- Zhu, D.*, Wu, Z.*, Cao, G.*, Li, J., Wei, J., Tsuge, T., Gu, H., Aoyama, T., and Qu, L.J. (2014). TRANSLUCENT GREEN, an ERF family transcription factor, controls water balance in Arabidopsis by activating the expression of aquaporin genes. Molecular Plant 7,601-615.
- Marquardt, S., Raitskin, O., Wu, Z., Liu, F., Sun, Q., and Dean, C. (2014). Functionalconsequences of splicing of the antisense transcript COOLAIR on FLC transcription.Molecular Cell 54, 156-165.
- Ietswaart, R., Wu, Z., and Dean, C. (2012). Flowering time control: another window to the connection between antisense RNA and chromatin. Trends in Genetics 28, 445-453.
研究领域
1. RNA结合蛋白在植物发育及环境响应中的作用范式
2. 植物中转录及其偶联的RNA命运决定
3. 植物生殖过程中组蛋白修饰的重编程
学术成果 查看更多
代表著作
1. Zhu, D., Wen, Y., Yao, W., Zheng, H., Zhou, S., Zhang, Q., Qu, L.J., Chen, X., and Wu, Z.# (2023). Distinct chromatin signatures in the Arabidopsis male gametophyte. Nature Genetics. 55:706-720. (co-corresponding author)
2. Zhou, S., Zhao, F., Zhu, D., Zhang Q., Dai Z., Wu Z.# (2023). Coupling of co-transcriptional splicing and 3′ end Pol II pausing pausing during termination in Arabidopsis. Genome Biology. 204:206. (co-corresponding author)
3. Chen L., Xu Z., Huang J., Shu, H., Hui, Y., Zhu, D., Wu, Y., Dong, S., Wu, Z.# Plant immunity suppressor SKPR encodes a novel RNA-binding protein that targets exon 3′ end of unspliced RNA. New Phytologist. 240:1467-1483.(co-corresponding author)
4. Yang, D., Zhao, F., Zhu, D., Chen, X., Kong, X., Wu, Y., Chen, M., Du, J., Qu, L.J., and Wu, Z.# (2022). Progressive chromatin silencing of ABA biosynthesis gene permits seed germination in Arabidopsis. The Plant Cell. 34:2871-2891. (corresponding author)
5. Zhang Q, Zhao F, Wu Z#, Zhu D#. (2022) A simple and robust method for isolating and analyzing chromatin-bound RNAs in Arabidopsis. Plant Methods 18:135. (co-corresponding author)
6. Xu, C*., Wu, Z*., Duan, H.C*., Fang, X., Jia, G., and Dean, C#. (2021). R-loop resolution promotes co-transcriptional chromatin silencing. Nat Commun 12, 1790. (co-first author)
7. Fang, X*., Wu, Z*., Raitskin, O., Webb, K., Voigt, P., Lu, T., Howard, M., and Dean, C#. (2020). The 3′ processing of antisense RNAs physically links to chromatin-based transcriptional control. Proc Natl Acad Sci U S A 117, 15316-15321. (co-first author)
8. Zhu D*., Mao F*., Tian Y., Lin X., Gu L., Gu H., Qu L.J., Wu Y#., and Wu Z#. (2020): The features and regulation of co-transcriptional splicing in Arabidopsis.Molecular Plant, 13, 278- 294. (co-corresponding author)
9. Wu Z*., Fang X., Zhu D., Dean C. (2020). Autonomous pathway: FLC repression through an antisense-mediated chromatin silencing mechanism. Plant Physiology 182, 27-37.
10. Ietswaart, R.*, Rosa, S.*, Wu, Z.*, Dean, C.#, and Howard, M#. (2017). Cell-size-dependent transcription of FLC and its antisense long non-coding RNA COOLAIR explain cell-to-cell expression variation. Cell Systems 4, 622-635 e629.(co-first author)
11. Wu, Z.*, Ietswaart, R.*, Liu, F., Yang, H., Howard, M., and Dean, C#. (2016). Quantitativeregulation of FLC via coordinated transcriptional initiation and elongation. PNAS 113,218-223.
12. Wu, Z.*, Zhu, D.*, Lin, X.*, Miao, J.*, Gu, L., Deng, X., Yang, Q., Sun, K., Cao, X., Tsuge, T., Dean, C., Aoyama, T., Gu, H., and Qu, L.J.# (2016). RNA-binding proteins RZ-1B andRZ-1C play critical roles in regulating pre-mRNA splicing and gene expression duringdevelopment in Arabidopsis. The Plant Cell 28, 55-73.
13. Wang, Z.W.*, Wu, Z.*, Raitskin, O., Sun, Q., and Dean, C.# (2014). Antisense-mediated FLCtranscriptional repression requires the P-TEFb transcription elongation factor. PNAS 111,7468-7473. (co-first author)
14. Zhu, D.*, Wu, Z.*, Cao, G.*, Li, J., Wei, J., Tsuge, T., Gu, H., Aoyama, T., and Qu, L.J. # (2014). TRANSLUCENT GREEN, an ERF family transcription factor, controls water balance in Arabidopsis by activating the expression of aquaporin genes. Molecular Plant 7,601-615. (co-first author)
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本实验室现有成员16人,主要由副研究员,博士后及博士研究生组成,实验室具有宽松同时健康向上的工作环境和氛围。本实验室长期有博士后和博士生的名额和机会。欢迎对植物发育,表观遗传以及生物信息学感兴趣的同学随时联系我们(wuz@sustech.edu.cn)。期待你的加入!