Assistant Professor Department of Biology

Prof. Sun obtained his Ph.D. degree from Hong Kong University of Science and Technology for Division of Life Science in 2009. At 2012, she joined Southern University of science and technology.

Personal Profile

Research

Cell-extracellular matrix (ECM) interactions are critically involved in multiple human diseases development and progression. The focal adhesion complexes consisting of integrin-linked kinase (ILK), PINCH and parvin (IPP complex) and Kindlin-2-migfillin complex that plays important roles in controlling integrin-mediated cell-ECM adhesion and signaling. The goal of my laboratory is to understand the function and molecular mechanism of these focal adhesion proteins in human diseases (particularly in cancer and glomerular disease) progression and to identify a number of novel focal adhesion proteins mediated signaling axis that may serve as useful targets for therapeutic control of cancer or glomerular disease.


Teaching

1.Introduction to Human Health and Diseases

2.Microbiology

3.Microbiology Lab

4.Frontier in Life Sciences Seminar and Journal Club


Publications Read More

1. Qian T#, Liu C#, Ding Y, Guo C, Cai R, Wang X, Wang R, Zhang K, Zhou L, Deng Y, Wu C*, Sun Y*. (2019) PINCH-1 interacts with myoferlin to promote breast cancer progression and metastasis. Oncogene. In press

2. Sun Y#*, Ding Y#, Guo C#, Liu C, Ma P, Ma S, Wang Z, Liu J, Qian T, Ma L, Deng Y, Wu C*. (2019). α-parvin promotes breast cancer progression and metastasis through interaction with G3BP2 and regulation of TWIST1 signaling. Oncogene. Jun;38(24):4856-4874.

3. Guo L*, Cui C, Zhang K, Wang J, Wang Y, Lu Y, Chen K, Yuan J, Xiao G, Tang B, Sun Y*, Wu C*. (2019). Kindlin-2 links mechano-environment to proline synthesis and tumor growth. Nat Commun. Feb 19;10(1):845.

4. Chu B#, He A#, Tian Y, He W, Chen P, Hu J, Xu R, Zhou W, Zhang M, Yang P, Sun Y*, Li P*, Hunter T, Tian R*. (2018). Photoaffinity engineered protein scaffold for systematically exploring native phosphotyrosine signaling complexes in tumor samples. Proc Natl Acad Sci U S A. 115(38):E8863-E8872.

5. Sun Y#*, Guo C#, Ma P, Lai Y, Yang F, Cai J, Sheng Y, Cheng Z, Tian R, Deng Y, Xiao G*, Wu C*. (2017). Kindlin-2 association with Rho GDP-Dissociation Inhibitor α suppresses Rac1 activation and podocyte injury. J Am Soc Nephrol. 2017 Dec;28 (12): 3545-3562.

6. Hu W#,Yu X#, Liu Z#, Sun Y, Chen X, Yang X, Li X, Lam W, Duan Y, Cao X, Steller H, Liu K, Huang P*. (2017). The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multipleadenylyl cyclase isoforms. Elife; 2017 Jun 28;6. pii: e28021.

7. Sun Y*, Huang P*. (2016). Adenosine A2B receptor: from cell biology to human diseases. Front Chem. 2016 Aug 24; 4:37.

8. Sun Y#, Hu W#, Yu X, Liu Z, Tarran R, Ravid K, Huang P*. (2016). Actinin-1 binds to the C-terminus of A2B adenosine receptor and enhances its cell surface expression. Biochem J. 2016 Jul 15;473(14):2179-86.

9. Xie C#, Cao X#, Chen X, Wang D, Zhang W, Sun Y, Hu W, Zhou Z, Wang Y, Huang P*. (2016). Mechanosensitivity of wild-type and G551D cystic fibrosis transmembrane conductance regulator (CFTR) controls regulatory volume decrease in simple epithelia. FASEB J. 2016 Apr; 30 (4):1579-89.

10. Duan Y, Sun Y, Zhang F, Zhang W, Wang D, Wang Y, Hu W, Xie C, Cuppoleti J, Margin T, Wang H, Wu Z, Li N, Huang P*. (2012). Keratin K18 increases CFTR surface expression by binding to its C-terminal hydrophobic patch. J Biol Chem. 287(48):40547-59.

11. Sun Y, Duan Y, Eisenstein A, Hu W, Quintana A, Lam WK, Wang Y, Wu Z, Ravid, K, Huang P*. (2012). A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors. J Cell Sci. 125(Pt 19):4507-17.

12. Sun Y# , Wu F# , Sun F, and Huang P*. (2008). Adenosine promotes IL-6 release in airway epithelia. J Immunol. 180(6):4173-81.

13. Wang D, Sun Y, Zhang W, and Huang P*. (2008). Apical adenosine regulates basolateral Ca++-activated potassium channels in human airway Calu-3 epithelial cells. Am J Physiol Cell Physiol. 294(6):C1443-53.

14. Wang D#, Wang W#, Duan Y, Sun Y, Wang Y, Huang P*. (2008). Functional coupling of Gs and CFTR is independent of their association with lipid rafts in epithelial cells. Pflugers Arch. 456(5):929-38.

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Contact Address

Office Phone

+86-755-88018412

Email

suny@sustech.edu.cn

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