Associate Professor Department of Biology

Zhiyi Wei, PhD

Associate Professor, Department of Biology

Biochemistry, Biophysics, Structural Biology, and Neurobiology

ORCID iD: 0000-0002-4446-6502

Personal Profile

Dr. Zhiyi Wei was attracted by the uniqueness of structural biology in understanding biology during his Ph.D. study. After his postdoctoral training at University of Washington, he joined the Hong Kong UST as a Research Assistant Professor. Currently, he is an Associate Professor at Southern University of Science and Technology. His research focus on decoding the mystery of how life is built up via dynamic interactions between proteins and between protein and other biomolecules at atomic level. We use structural biology approach, combining with biochemistry and cell biology approaches, to dissect the structures and regulatory mechanisms of key protein complexes underlying various cellular processes, especially membrane-related events in neuronal development. Since 2009, he has published more than 20 high impact research papers in international journals, including NatureScience, Cell, Molecular Cell, and PNAS.


Research Interests
◆ Molecular mechanism of neuronal development and related diseases
◆ Assembly mechanisms of membrane microdomains
◆ Intracellular trafficking of membrane compartments
◆ Transmembrane signalings
◆ Protein machines


Professional Experience
◆ 2013 – present, Associate Professor, Department of Biology, Southern University of Science and Technology of China
◆ 2009 – 2013, Research Associate Professor, Division of Life Science, Hong Kong University of Science and Technology
◆ 2007 – 2009, Research Fellow, School of Medicine, University of Washington


Educational Background
◆ 2007, Ph.D., Biochemistry & Molecular Biology, University of Science and Technology of China
◆ 2002, B.S., Biology, University of Science and Technology of China


Honors & Awards
◆ Oversea High-Caliber Personnel (Level B), Shenzhen Government, 2014
◆ Tin Ka Ping Fellow, Hong Kong University of Science and Technology, 2011-2013
◆ Outstanding Graduate, University of Science and Technology of China, 2007


Publications Read More

News More

  • SUSTech Research Group Makes Breakthrough in Anti-Inflammatory Drugs

    Original link: Associate Professor Wei Zhiyi from the Department of Biology at Southern University of Science and Technology (SUSTech) has published two papers with his colleague Assistant Professor Zhang Cheng from the Department of Medicine at the University of Pittsburgh. Their papers were published in Cell magazine’s "Molecular Cell" and Nature magazine’s "Nature Structural & […]

  • Congratulation to Ling Luo‘s Graduation!

  • Shenzhen Economic Daily: SUSTech’s Associate Professor Wei Zhiyi Explores the Wonders of Life

    Original link: Usually, it takes years or more than a decade for scientists to get their articles published in the scientific journal Nature. However, Associate Professor Zhiyi Wei and his team managed to publish a Nature letter entitled “Crystal Structure of the RNA-Guided Immune Surveillance Cascade Complex in Escherichia coli” in a matter of […]


Lab members Read More

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Currently, two postdoctoral positions are avaliable. Applicants should hold PhD degree with strong biochemistry or structural biology background. Please send your CV and two reference letters to

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