Professer School of Medicine

Xue-Jun Song, MD, PhD, Professor, Director of SUSTech Center for Pain Medicine, SUSTech School of Medicine.

Dr. Song obtained his Ph.D. in Neurobiology from Chinese Academy of Sciences Institute of Neuroscience in 1995 and then worked as postdoctoral fellow at Yale University School of Medicine. He was then serving as a faculty at University of Texas Medical Center and Parker University for eighteen years and at Peking University Health Science Center for five years. Dr. Song is currently serving as a tenured professor at Southern University of Science and Technology (SUSTech). He is also serving as members of the Scientific Committee, Membership Committee, and Pain-Terminology Definition Committee of the International Association for the Study of Pain (IASP), Member of Science and Education Committee of American Academy of Pain Medicine (AAPM), President of Chinese Association for the Study of Pain and China Chapter of IASP, Councilor of Chinese Neuroscience Society, Vice Chair of Chinese Pharmacological Society Anesthetic-Pharmacology Committee and Chinese Physiological Society Translational Pain Committee, as well as Senior/Section Editor of Pain Medicine, Associate Editor of Neurobiology of Pain and PainReports, and Senior Editor of Chinese J Pain Medicine.

Dr. Song has dedicated to basic science research and clinical practice in the fields of neuroscience, pain medicine and anesthesiology over thirty years. He has been a leading scientist in research of the primary and secondary sensory neuron excitability, synaptic plasticity, and the intracellular signaling transduction, particularly roles of Wnt signaling and ephrinB-EphB receptor signaling in neuropathic and cancer pain as well as opiate actions. His research has been funded by the key national and international research grants from China, the United States, and Australia, and has resulted in dozens of high quality original research articles published in peer-reviewed journals including the Anesthesiology, Brain, Cancer Res, J Clin Invest, J Neurosci, Nat Neurosci, Pain, etc., as well as international invention patents. Many of his research outcomes were highlighted by major scientific organizations including American Physiological Society, American Association of Cancer Research, the key media including NBC, CBS, etc., and the scientific journals including Nat Rev Drug Dis, PainResForum, etc., as well as recognized by the prestigious national and international scientific awards including the AAPM 2018 Robert Adison Award, The Scott Haldeman Award and The Louis Sportelli NCMIC Award from WFC, Outstanding Young Scientist Award from NSFC, and Science and Technology Awards from Chinese Ministry of Education, Chinese Academy of Sciences. In university education and teaching and advising undergraduate and graduate students, Dr. Song has made significant progress and achievements, for instance, one of his students at Peking University won the Rhodes Scholar from Oxford University in 2016 (only medical student in China won the honor of Rhodes Scholar in history to date).

Personal Profile

Self-Introduction

Xue-Jun Song, MD, PhD, Professor of Neurobiology and Pain Medicine, Department of Biology, College of Life Sciences, and Director of SUSTech Center for Pain Medicine, Southern University of Science and Technology (SUSTech). Dr. Song obtained his medical degree and had residency training in anesthesiology from Xuzhou Medical University, and PhD in neurobiology from Institute of Neuroscience, Chinese Academy of Sciences, had his postdoctoral training in Section of Neurobiology and Department of Neurobiology at Yale University School of Medicine. Dr. Song then served as a faculty at the University of Texas Medical Center and Parker University for a total of nineteen years and Peking University for five years before he joined SUSTech in 2016. Dr. Song’s research has been mainly in the field of sensory neuroscience particularly focusing on understanding mechanisms of neuropathic and cancer pain, opiate actions, and general anesthesia. Dr. Song and his team have published nearly a hundred original research articles in the prestigious peer-reviewed journals including Anesthesiology, Brain, Cancer Res, J Clin Invest, J Neurosci, Nat Neurosci, Pain, etc., and several patents of new drug discovery and pain treatment. Many of his research outcomes were highlighted by major scientific organizations including American Physiological Society, American Association of Cancer Research, the key international media NBC, CBS, and the scientific journals Nature Review Drug Discovery, Nature Publishing Group, PainResForum, and recognized by the prestigious national and international scientific awards including the outstanding contribution award to pain medicine “2018 Robert Addison Award” from American Academy of Pain Medicine (AAPM), Scott Haldeman Award and The Louis Sportelli NCMIC Award from World Federation of Chiropractic and Education, Natural Science Foundation of China grant award for Outstanding Young Scientists, First and Second Class Award of Science and Technology Advancement from Chinese Ministry of Education and Chinese Academy of Sciences, respectively, etc. Dr. Song currently services as President of Chinese Association for the Study of Pain and China Chapter of International Association for the Study of Pain (IASP), members of IASP Scientific Program Committee and Pain Definition Committee, AAPM Scientific and Education Committee, Vice Chairs of Translational Pain Research Committee of Chinese Physiological Society and Chinese Society for Anesthesia-Pharmacology, etc. He also services as an associate editor and editorial board members of PAIN Reports, Neurobiology of Pain, Pain Medicine, and Chinese J Pain Medicine.

 

Research Interests

  • Sensory neuron excitability, synaptic plasticity, and signal transduction; Mechanisms underlying neuropathic and cancer pain and development of new drug and technology for pain treatment;
  • Cellular and molecular mechanisms underlying opiate actions
  • Neural regulation and modulation of conscious state and general anesthesia
  • Neural circuit of empathy; empathy in neuropsychiatric disorders; empathy in artificial intelligence.  

Professional Experience

2017— Professor, Department of Biology, College of Life Sciences and Member of Medical School Planning Committee, Director of SUSTech Center for Pain Medicine, SUSTech, Shenzhen.

2012—2017 Professor of Neurobiology and Pain Medicine, and Director of Laboratory of Pain Plasticity, Neuroscience Research Institute and Department of Neurobiology, Co-Founder, Executive Director, and Vice Chair of its Academic Advisory Committee, Center for Pain Medicine, Peking University Health Science Center, Beijing.

1999—2016 Senior Research Scientist and Assistant-, Associate- and full Professor,  Director of Section of Basic Science Research, Associate Director of Parker Research Institute, Parker University, Dallas, Texas.

1998—1999 Instructor- Research Assistant Professor, The University of Texas Medical Center, Houston, Texas.

 
1995—1998 Postdoctoral Fellow, Department of Anesthesiology and Section of Neurobiology, Yale University School of Medicine, New Haven, CT.

 
1986—1995 Instructor/Anesthesiologist/Associate Professor, Department of Physiology and Department of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu.

2006—2012 (Joint position) Professor of Neuroscience and Anesthesiology, Institute of Neuroscience and Department of Anesthesiology in Xijing Hospital, The Fourth Military Medical University, Xi’an, Shanxi.

2005—2010 (Joint position) Distinguished Professor of Anesthesiology, Director of Jiangsu Province Key Lab of Anesthesiology, Vice Dean of College of Anesthesiology, and Director of Pain Research and Management Center, Xuzhou Medical University

 

Educational Background
1981-1986 MB/MD in Medicine, Xuzhou Medical University
1989-1992 MS/MD in Anesthesiology, Xuzhou Medical University
1992-1995 PhD in Neurobiology, Institute of Neuroscience, Chinese Academy of Sciences

Honors & Awards
2018 American Academy of Pain Medicine Robert Addison Award for Outstanding Contributions to Pain Medicine

2017 Shenzhen High-Level Talent Award

2015 The Louis Sportelli NCMIC Award, WFC, Athens, Greece
2014 Distinguished Medical Expert, Jiangsu Province Government, China
2006 Extraordinary Young Scientist Award, National Nature Science Foundation of China
2006 Parker University Outstanding Professorship Award for Outstanding Contributions to Sciences

2005 The Scott Haledeman Award, WFC, Sydney, Australia
2005 Outstanding Professorship Award, Parker University
2005 Researcher of the Year, Activator International LTD, USA
2004 Award of Advancement of Science and Technology (first class), Ministry of Education
1999 Award of Natural Science (second class), Chinese Academy of Sciences
1995 Outstanding Young Scientist Award, Chinese Academy of Sciences Shanghai
1994 Presidential Award, Chinese Academy of Sciences
1993 Research Award for National Young Scientists (second class), Zhang Xijun Foundation, Chinese Physiological Society

 

 

Selected recent original publications
1. Xu N, Wu MZ, Deng XT, Ma PC, Li ZH, Liang L, Song XJ. Inhibition of YAP/TAZ Activity in Spinal Cord Suppresses Neuropathic Pain. J Neurosci 2016; 36(39):10128 –10140. 

  1. Liu S, Liu YP, Huang ZJ, Zhang YK, Song AA, Ma PC, Song XJ. Wnt/Ryk signaling contributes to neuropathic pain by regulating sensory neuron excitability and spinal synaptic plasticity in rats. Pain2015; 156(12):2572-84.
    3. Zhang YK, Huang ZJ, Liu S, Liu YP, Song AA, Song XJ. WNT signaling underlies the pathogenesis of neuropathic pain in rodents. J Clin Invest2013; 123(5):2268-86.
    4. Liu S, Liu YP, Song WB, Song XJ. EphrinB-EphB receptor signaling contributes to bone cancer pain via Toll-like receptor and proinflammatory cytokines in rat spinal cord. Pain 2013;154(12):2823-35.
    5. Huang ZJ, Li HC, Cowan AA, Zhang YK, Song XJ. Chronic compression or acute dissociation of dorsal root ganglion induces cAMP-dependent neuronal hyperexcitability through activation of PAR2. Pain 2012, 153:1426-1437.
    6. Wu XF, Liu WT, Liu YP, Huang ZJ, Zhang YK, Song XJ. Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord. Pain 2011; 152:2605-2613.
    7. Liu S, Liu WT, Liu YP, Dong HL, Henkemeyer M, Song XJ. Blocking EphB1 receptor forward signaling in spinal cord relieves bone cancer pain and rescues analgesic effect of morphine treatment in rodents. Cancer Research 2011;71(13): 4392-402.
    8. Liu WT, Han Y, Liu YP, Song AA, Barnes B, Song XJ. Spinal matrix metalloproteinase-9 contributes to physical dependence on morphine in mice.

J Neurosci, 2010; 30: 7613-7623.
9. Liu WT, Li HC, Song XS, Huang ZJ, Song XJ. EphB receptor signaling in mouse spinal cord contributes to physical dependence on morphine. FASEB J 2009; 23(1):90-98.
10. Song XS, Huang ZJ, Song XJ. Thiamine may suppress thermal hyperalgesia by inhibiting hyperexcitability and regulating altered sodium channel of the injured dorsal root ganglion neurons in rats. Anesthesiology 2009; 110:387-400.

Research

1. Sensory neuron excitability, synaptic plasticity, and intracellular signal transduction;

2. Cellular and molecular mechanisms underlying chronic pain after nerve injury, cancer, or diabetes as well as opiate actions; new drug and technology research and development for chronic pain treatment

3. Neural mechanisms underlying general anesthesia, awakening, and consciousness

4. Empathy: neural circuits and application in the artificial intelligence


Teaching

Teaching undergraduate and graduate students in medical schools in Physiology, Neurobiology, Neuroscience Research Methods, Neuropharmacology, and Pain Medicine in the past more than three decades.


Publications Read More

1. Wu MZ, Li ZH, Liang L, Ma PC, Cui D, Chen P, Wu GH, Song XJ. Wnt signaling contributes to withdrawal symptoms from opioid receptor activation induced by morphine exposure or chronic inflammation. Pain (2019 Nov, in press)

2. Xu N, Wu MZ, Deng XT, Ma PC, Li ZH, Liang L, Song XJ. Inhibition of YAP/TAZ Activity in Spinal Cord Suppresses Neuropathic Pain. J Neurosci 2016; 36(39):10128-40.

3. Liu S, Liu YP, Huang ZJ, Zhang YK, Song AA, Ma PC, Song XJ. Wnt/Ryk signaling contributes to neuropathic pain by regulating sensory neuron excitability and spinal synaptic plasticity in rats. Pain 2015; 156(12):2572-84.

4. Liu S, Liu YP, Song WB, Song XJ. EphrinB-EphB receptor signaling contributes to bone cancer pain via Toll-like receptor and proinflammatory cytokines in rat spinal cord. Pain, 2013;154(12):2823-35.

5. Zhang YK, Huang ZJ, Liu S, Liu YP, Song AA, Song XJ. WNT signaling underlies the pathogenesis of neuropathic pain in rodents. J Clin Invest 2013; 123(5):2268-86.

6. Huang ZJ, Li HC, Cowan AA, Zhang YK, Song XJ. Chronic compression or acute dissociation of dorsal root ganglion induces cAMP-dependent neuronal hyperexcitability through activation of PAR2. Pain 2012; 153:1426-1437.

7. Wu XF, Liu WT, Liu YP, Huang ZJ, Zhang YK, Song XJ. Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord. Pain 2011;152:2605-2613.

8. Liu S, Liu WT, Liu YP, Dong HL, Henkemeyer M, Song XJ. Blocking EphB1 receptor forward signaling in spinal cord relieves bone cancer pain and rescues analgesic effect of morphine treatment in Cancer Res 2011;71(13):4392-402.

9. Liu WT, Han Y, Liu YP, Song AA, Barnes B, Song XJ. Spinal matrix metalloproteinase-9 contributes to physical dependence on morphine in mice. J Neurosci, 2010; 30: 7613-7623.

10. Liu WT, Li HC, Song XS, Huang ZJ, Song XJ. EphB receptor signaling in mouse spinal cord contributes to physical dependence on m FASEB J 2009; 23(1):90-98.

11. Song XS, Huang ZJ, Song XJ. Thiamine may suppress thermal hyperalgesia by inhibiting hyperexcitability and regulating altered sodium channel of the injured dorsal root ganglion neurons in rats. Anesthesiology 2009; 110:387-400.

News More

  • Vitamin B for Back Pain

    A combination of B vitamins effectively cuts down chronic aches. Information on research that on how B vitamins were effective in relieving chronic neuropathic pain, pain generated not from some physical cause, but by the nerves themselves. By Anne Becker, published at Psychology Today on May 27, 2003  It's no secret that B vitamins are nutritionally important – they're necessary […]

    2019-11-11
  • China Unveils Medical Education System’s First Comprehensive Pain Center

    May 17, 2017 China has established the Center for Pain Medicine at Southern University of Science and Technology (SUSTech) in Shenzhen, the first free-standing center and department of pain medicine in the Chinese medical education system. The center will integrate basic and clinical research into undergraduate, graduate, and postgraduate education and training and will incorporate […]

    2019-11-11

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Email

songxuejun@sustech.edu.cn

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