Assistant Professor School of Sciences

Our group is mainly focused on the RNA regulation of B cell biology. We found that disruption of specific RNA processing and modification pathways would impair B cell development and humoral immune responses. We are trying to identify the RNA substrates and figure out how these pathways are linked to modulating B cell development and differentiation.

Personal Profile

WORK EXPERIENCE:
2016-present, Assistant Professor, Department of Biology, SUSTech
2015-2016, Associate Staff Scientist, Bioprocessing Technology Institute, Singapore
2009-2015, Research Scientist, Bioprocessing Technology Institute, Singapore

EDUCATION:
2002-2009, Ph.D. (Microbiology), Fudan University, China
1997-2001, B.Sc. (Microbiology), Huazhong Agricultural University, China

Research

1. B Cell Development

2. Humoral Immune Response


Teaching

1. Microbiology (undergraduate)

2. Cellular and Molecular Immunology (postgraduate)


Publications Read More

1. Xu S, Huo J, Huang Y, Aw M, Chen S, Mak S, Yip LY, Ho YS, Ng SW, Tan AH, Lee A, Ou X, Lam KP. von Hippel-Lindau Protein Maintains Metabolic Balance to Regulate the Survival of Naive B Lymphocytes. iScience. 2019 Jul 26;17:379-392.

2. Ou X*, Huo J, Huang Y, Li YF, Xu S*, Lam KP*. Transcription factor YY1 is essential for iNKT cell development. Cellular & Molecular Immunology. 2018 Mar 2. doi: 10.1038/s41423-018-0002-6. (*co-corresponding author)

3. Li YF, Xu S, Huang Y, Ou X, Lam KP. Tyrosine kinase c-Abl regulates the survival of plasma cells. Scientific Reports. 2017 Jan 6;7:40133.

4. Li YF#, Ou X#, Xu S, Jin ZB, Iwai N, Lam KP. Loss of miR-182 affects B-cell extrafollicular antibody response. Immunology 2016, 148(2):140-9. (#co-first author)

5. Xu S#, Ou X#, Huo J, Lim K, Huang Y, Chee S, Lam KP. Mir-17-92 regulates bone marrow homing of plasma cells and production of immunoglobulin G2c. Nature Communications 2015, 6:6764. (#co-first author)

6. Li YF, Lee KG, Ou X, Lam KP. Bruton's tyrosine kinase and protein kinase C µ are required for TLR7/9-induced IKKα and IRF-1 activation and interferon-β production in conventional dendritic cells. PLoS One 2014, 9(8):e105420.

7. Ou X, Xu S, Li YF, Lam KP. Adaptor protein DOK3 promotes plasma cell differentiation by regulating the expression of programmed cell death 1 ligands. PNAS 2014, 111(31):11431-6.

8. Li YF, Xu S, Ou X, Lam KP. Shp1 signalling is required to establish the long-lived bone marrow plasma cell pool. Nature Communications 2014, 5:4273.

9. Ou X, Xu S, Lam KP. Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival. PNAS 2012, 109(38):15401-6.

10. Zhang X, Bao Y, Shi X, Ou X, Zhou P, Ding X. Efficient transposition of IS204-derived plasmids in Streptomyces coelicolor. Journal of Microbiological Methods 2012, 88(1):67-72.

11. Zhang L, Wang L, Wang J, Ou X, Zhao G, Ding X. DNA cleavage is independent of synapsis during Streptomyces phage phiBT1 integrase-mediated site-specific recombination. Journal of Molecular Cell Biology 2010, 2(5):264-75.

12. Ou X, Zhang B, Zhang L, Zhao G, Ding X. Characterization of rrdA, a TetR family protein gene involved in the regulation of secondary metabolism in Streptomyces coelicolor. Applied and Environmental Microbiology 2009, 75(7):2158-65.

13. Ou X, Zhang B, Zhang L, Dong K, Liu C, Zhao G, Ding X. SarA influences the sporulation and secondary metabolism in Streptomyces coelicolor M145. Acta Biochimica et Biophysica Sinica 2008, 40(10):877-82.

14. Zhang L, Ou X, Zhao G, Ding X. Highly efficient in vitro site-specific recombination system based on streptomyces phage phiBT1 integrase. Journal of Bacteriology 2008, 190(19):6392-7.

News More

Lab members Read More

Join us

Contact Us

Contact Address

1088 Xueyuan Blvd., Nanshan District, Shenzhen, Guangdong, China 518055

Office Phone

0755-88018402

Email

ouxj@sustech.edu.cn

Copyright © 2018 All Rights Reserved.