Assistant Professor Department of Ocean Science and Engineering

Dr. Kai P. Law is a senior researcher specialized in biological and clinical mass spectrometry with extensive knowledge and skills in metabolomics/lipidomics and proteomics, and associated informatics. Dr. Law gained his Ph.D. from the School of Pharmacy, University of Nottingham, UK, in 2008. Since then he continued his career as a postdoctoral researcher in the Clinical Science Research Institute, University of Warwick, UK; the School of Science, University of Greenwich, UK; and the Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore. He was a senior experimental officer, leading the development of the Mass Spectrometry Centre, at Chongqing Medical University, before he joined SUSTech. Dr. Law has published extensively as the first and principal author. His most significant works include development of a surface assistant laser desorption/ionization technique based on nanostructured surface, an investigation of data-independent acquisition approaches for quantitative proteomics and the pathophysiology of gestational diabetes mellitus. Dr. Law currently is implementing an ion mobility mass spectrometry protocol for comprehensive analysis of archaeal lipidome, investigating their physiological changes related to changes in environmental factors, and the ecological roles of these microorganisms in marine systems.

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1. ion mobility mass spectrometry

2. lipidomics

3. metabolomics

4. multivariate statistics

5. cheminformatics

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Dr. Law has published 16 articles, mostly as the first and/or corresponding author:

• Kai P. Law* and Chuanlun L. Zhang. Current Progress and Future Trends of Mass Spectrometry-based Archaeal Lipidomics. Organic Geochemistry, 134 (2019) 45–61.

• Xun Mao, Xuyang Chen, Chang Chena, Hua Zhang, Kai P. Law*. Metabolomics in gestational diabetes. Clinica Chimica Acta, 475 (2017) 116–127.

• Ting-Li Han, Ying Yang, Hua Zhang, Kai P. Law*. Analytical Challenges of Untargeted GC-MS-based Metabolomics and the Critical Issues in Selecting the Data Processing Strategy. F1000Research 2017, 6:967.

• Kai P. Law* and Hua Zhang. The Pathogenesis and Pathophysiology of Gestational Diabetes Mellitus: Deductions from a Three-part Longitudinal Metabolomics Study in China. Clinica Chimica Acta, 468 (2017) 60–70.

• Kai P. Law*, Ting-Li Han, Xun Mao, and Hua Zhang. Tryptophan and Purine Metabolites are consistently upregulated in the Urinary Metabolome of Patients Diagnosed with Gestational Diabetes Mellitus throughout Pregnancy: A Longitudinal Metabolomics Study of Chinese Pregnant Women Part 2. Clinica Chimica Acta, 468 (2017) 126–139.

• Kai P. Law*, Xun Mao, Ting-Li Han, and Hua Zhang. Unsaturated Plasma Phospholipids are consistently lower in the Patients Diagnosed with Gestational Diabetes Mellitus throughout the Gestation: A Longitudinal Metabolomics Study of Chinese Pregnant Women Part 1. Clinica Chimica Acta. 465 (2017) 53–71.

• Yue Wang, Linqiang Ma, Xiaoyu Shu, Jiayu Li, Jinbo Hu, Kai P. Law, Ting Luo, Richa Goswami, Shumin Yang, Suhua Zhang, and Qifu Li. Apparent mineralocorticoid excess caused by a novel mutation in 11-hydroxysteroid dehydrogenase type 2 gene. Journal of Hypertension, 35 (3), 647-650 (2017).

• Aihua Hou, Kai Pong Law, Min Qi Tin, and Louis Tong. In vitro Secretomics study of Pterygium-derived Fibroblasts by iTRAQ-based Quantitative Proteomics Strategy. Experimental Eye Research. 153, 14–22 (2016). Equally contributed author.

• Kai P. Law*, and Ting-Li Han. The Importance of Suitable GC-MS Date Processing and Analysis for Environmental Metabolomics. Environmental Science and Pollution Research 23 (10) 0276-10285, (2016).

• Kai P. Law*, Ting-Li Han, Philip N. Baker. Mass Spectrometry-based Proteomics for Pre-eclampsia and Preterm Birth. International Journal of Molecular Sciences 16 (5), 10952­10985 (2015)

• P. V. Iyengar, P. Jaynes, L. Rodon, D. Lama, Kai P. Law, C. Verma, J. Seoane & P. J. A. Eichhorn. USP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination. Nature, Scientific Reports, 5, 14755 (2015).

• A. Hou, W. Lan, Kai P. Law, SCJ Khoo, M.Q. Tin, L. Tong. Evaluation of Global Differential Gene and Protein Expression in Primary Pterygium: S100A8 and S100A9 as Possible Drivers of a Signaling Network. PLoS ONE 9(5): e97402 (2014).

• Kai P. Law*. Recent Advances in Mass Spectrometry: Data Independent Analysis and Hyper Reaction Monitoring. Expert Review of Proteomics 10 (2013) 551-566.

• K.P. Law* and James R. Larkin. Recent Advances in SALDI-MS Techniques and Their Chemical and Bioanalytical Applications. Analytical and Bioanalytical Chemistry 399 (2011) 8 2597-2622.

• K.P. Law*. Laser Desorption/Ionization Mass Spectrometry on Nanostructured Semiconductor Substrates: DIOS™ and QuickMass™. International Journal of Mass Spectrometry 290 (2010) 72-84.

• K.P. Law*. Surface-Assisted Laser Desorption/Ionization Mass Spectrometry on Nanostructured Silicon Substrates Prepared by Iodine-assisted Etching. International Journal of Mass Spectrometry 290 (2010) 47-59.

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