Associate Professor Department of Biomedical Engineering

Li Kai, an associate professor in the Department of Biomedical Engineering, Southern University of Science and Technology,who was Selected in the National Special Expert Youth Project and the Imaging Materials Branch of the Chinese Society of Biomaterials. The main research directions are the development of new molecular probes and nanoprobes and their applications in biomedicine. Dr. Lee received his Ph. D. degree from National University of Singapore in 2011. He systematically studied the application of conjugated polymers and aggregated induced luminescent nanoparticles as novel fluorescent probes in stem cell tracing and cancer diagnosis and treatment, and won the National Outstanding Student Scholarship at his own expense. Later, he joined the Institute of Materials and Engineering of the Singapore Bureau of Science and Technology Research as a research scientist and was awarded Career Development Award of the Singapore Bureau of Science and Technology Research in 2013. From 2015 to 2017, he joined the Molecular Imaging Center of Stanford University Medical College as a visiting scholar for collaborative research. The AIE fluorescent nanoparticles and cell tracers developed have been reported by Nature magazine on the topic of "The nanolight revolution is coming". So far, four PCT patents have been applied for, one Singapore patent has been authorized, and more than 5,900 academic papers have been cited. At present, the H-index is 40, presiding over the project 1 on the National Natural Science Foundation. Item.

Personal Profile

Li Kai, an associate professor in the Department of Biomedical Engineering, Southern University of Science and Technology, was Selected in the National Special Expert Youth Project and the Imaging Materials Branch of the Chinese Society of Biomaterials. The main research directions are the development of new molecular probes and nanoprobes and their applications in biomedicine. Dr. Lee received his Ph. D. degree from National University of Singapore in 2011. He systematically studied the application of conjugated polymers and aggregated induced luminescent nanoparticles as novel fluorescent probes in stem cell tracing and cancer diagnosis and treatment, and won the National Outstanding Student Scholarship at his own expense. Later, he joined the Institute of Materials and Engineering of the Singapore Bureau of Science and Technology Research as a research scientist and was awarded Career Development Award of the Singapore Bureau of Science and Technology Research in 2013. From 2015 to 2017, he joined the Molecular Imaging Center of Stanford University Medical College as a visiting scholar for collaborative research. The AIE fluorescent nanoparticles and cell tracers developed have been reported by Nature magazine on the topic of "The nanolight revolution is coming". So far, four PCT patents have been applied for, one Singapore patent has been authorized, and more than 5,700 academic papers have been cited. At present, the H-index is 39, presiding over the project 1 on the National Natural Science Foundation. Item.

 

 

Professional Experience

2011.07-present Scientist, PI Institute of Materials Research & Engineering, A*STAR, Singapore

2015.08-2017.07 Visiting Scholar Molecular Imaging Program at Stanford, Stanford University, United States

2006.07-2007.12 Technician SK Energy, Beijing Representative Office, China

Education

2011 Ph.D., Department of Chemical and Biomolecular Engineering National University of Singapore (NUS), Singapore 

2006 M.E., Department of Polymer Engineering  Chungnam National University (CNU), Korea 

2003 B.E., Department of Polymer Science and Engineering  Beijing University of Chemical Technology (BUCT), China

Awards and Honors

2019 Shenzhen Overseas High-level Talents B, Guangdong Excellent Talents and Nanshan Pilot Talents

2018 National Special Expert Youth Project

2016 World Molecular Imaging Congress (WMIC) 2016 Travel Award 

2016 Finalist, World Molecular Imaging Congress (WMIC) 2016 Best Poster Award 

2015 A*STAR International Fellowship 

2013 2nd JCO Career Development Award (CDA), JCO, A*STAR 

2011 Chinese Government Award for Outstanding Self-financed Students Abroad (2010) 

2008-2011 President’s Graduate Fellowship (NUS) 

2004-2006 Korea Science and Engineering Foundation (KOSEF) Scholarship for Foreign Students

2003 Outstanding University Graduate Award (Beijing)

2003 Outstanding Undergraduate Thesis Award (BUCT)  

2000,2001 Champion of soccer league (School of Materials Science and Engineering, BUCT) 

1999-2003 People’s Scholarship Award (7 times, BUCT) 

 

Representative Paper

1.Xulei Qin, Haodong Chen, Huaxiao Yang, Haodi Wu, Xin Zhao, Huiyuan Wang, Tony Chour, Evgenios Neofytou, Dan Ding, Heike Daldrup-Link, Sarah C. Heilshorn, Kai Li,* Joseph C. Wu,* Photoacoustic imaging of embryonic stem cell-derived cardiomyocytes in living hearts with ultrasensitive semiconducting polymer nanoparticles. Adv. Funct. Mater. 2018, 28, 1704939.

2.Heqi Gao, Xiaoyan Zhang, Chao Chen, Kai Li,* Dan Ding.* Unity makes strength: how aggregation-induced emission luminogens advance the biomedical field. Adv. Biosys. 2018, 2, 1800074 (Invited Review).

3.Kai Li,* Hossein Nejadnik, Heike E. Daldrup-Link,* Next generation superparamagnetic iron oxide nanoparticles for cancer theranostics. Drug Discov. Today 2017, 22, 1421-1429 (Invited Review).

4.Guorui Jin, Guangxue Feng, Wei Qin, Ben Zhong Tang, Bin Liu,* Kai Li,* Multifunctional organic nanoparticles with aggregation-induced emission (AIE) characteristics for targeted photodynamic therapy and RNA interference therapy. Chem. Commun. 2016, 52, 2752-2755 (*corresponding author).

5.Guorui Jin, Duo Mao, Pingqiang Cai, Rongrong Liu, Nikodem Tomczak, Jie Liu, Xiaodong Chen, Deling Kong, Dan Ding,* Bin Liu,* Kai Li,* Conjugated polymer nanodots as ultrastable long-term trackers to understand mesenchymal stem cell therapy in skin regeneration. Adv. Funct. Mater. 2015, 25, 4263-4273 (Frontispiece Story).

6.Jie Liu, Kai Li,* Bin Liu,* Far-red/near-infrared conjugated polymer nanoparticles for long-term in-situ monitoring of liver tumor growth. Adv. Sci. 2015, 2, 1500008.

7.Kai Li, Bin Liu, Polymer-encapsulated organic nanoparticles for fluorescence and photoacoustic imaging. Chem. Soc. Rev. 2014, 43, 6570-6597.

8.Dan Ding,† Duo Mao,† Kai Li,† Xiaomin Wang, Wei Qin, Rongrong Liu, David Shunzhong Chiam, Nikodem Tomczak, Zhimou Yang, Ben Zhong Tang, Deling Kong, Bin Liu (†contributed equally), Precise and long-term tracking of adipose-derived stem cells and their regenerative capacity via superb bright and stable organic nanodots. ACS Nano 2014, 8, 12620-12631.

9.Wei Qin,† Kai Li,† Guangxue Feng, Min Li, Zhiyong Yang, Bin Liu, Ben Zhong Tang, Bright and photostable organic fluorescent dots with aggregation-induced emission characteristics for noninvasive long-term cell imaging. Adv. Funct. Mater. 2014, 24, 635-643 (†contributed equally).

10.Guangxue Feng,† Kai Li,† Jie Liu, Dan Ding, Bin Liu, Bright single-chain conjugated polymer dots embedded nanoparticles for long-term cell tracing and imaging. Small 2014, 10, 1212-1219 (†contributed equally).

11.Kai Li, Wei Qin, Dan Ding, Nikodem Tomczak, Junlong Geng, Rongrong Liu, Jianzhao Liu, Xinhai Zhang, Hongyu Liu, Bin Liu, Ben Zhong Tang, Photostable fluorescent organic dots with aggregation-induced emission (AIE dots) for noninvasive long-term cell tracing. Sci. Rep. 2013, 3, 1150 (Highlighted by Nature News).

12.Kai Li, Zhenshu Zhu, Zujin Zhao, Nikodem Tomczak, Pingqiang Cai, Rongrong Liu, Jie Liu, Wei Qin, Yong Hu, Xiaodong Chen, Ben Zhong Tang, Bin Liu, Organic dots with aggregation-induced emission (AIE dots) characteristics for dual-color cell tracing. Chem. Mater. 2013, 25, 4181-4187.

13.Kai Li, Dan Ding, Da Huo, Kan-Yi Pu, Ngo Nguyen Phuong Thao, Yong Hu, Zhi Li, Bin Liu, Conjugated polymer based nanoparticles as dual-modal probes for targeted in vivo fluorescence and magnetic resonance imaging. Adv. Funct. Mater. 2012, 22, 3107-3115.

14.Kai Li, Yutao Liu, Kan-Yi Pu, Si-Shen Feng, Ruoyu Zhan, Bin Liu, Polyhedral oligomeric silsesquioxanes-containing conjugated polymer loaded PLGA nanoparticles with Trastuzumab (Herceptin) functionalization for HER2-positive cancer cell detection. Adv. Funct. Mater. 2011, 21, 287-294 (Inside Front Cover Story).

15.Kai Li, Jie Pan, Si-Shen Feng, Arthur Wenqing Wu, Kan-Yi Pu, Yutao Liu, Bin Liu, Generic strategy of preparing fluorescent conjugated polymer-loaded poly(dl-lactide-co-glycolide) nanoparticles for targeted cell imaging. Adv. Funct. Mater. 2009, 19, 3535-3542 (Frontispiece Story).

Research

Nanomedicine, molecular imaging, molecular probes


Teaching

Course: nano biomedicine(Graduate student)


Publications Read More

1. Huaxiao Yang,* Xulei Qin, Huiyuan Wang, Xin Zhao, Yonggang Liu, Hung-Ta Wo, Chun Liu, Masataka Nishiga, Haodong Chen, Jing Ge, Nazish Sayed, Oscar J. Abilez, Dan Ding, Sarah C. Heilshorn, Kai Li.* An in vivo miRNA delivery system for restoring infarcted myocardium. ACS Nano 2019, doi: 10.1021/acsnano.9b03343.

2. Guorui Jin, Rongyan He, Qian Liu, Min Lin, Yuqing Dong, Kai Li, Ben Zhong Tang, Bin Liu, Feng Xu. Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles. Theranostics 2019, 9, 246-264.

3. Xin-Chi Jiang, Jia-Jia Xiang, Hong-Hui Wu, Tian-Yuan Zhang, Dan-Ping Zhang, Qian-Hao Xu, Xiao-Li Huang, Xiang-Lei Kong, Ji-Hong Sun, Yu-Lan Hu, Kai Li, Yasuhiko Tabata, You-Qing Shen, Jian-Qing Gao. Neural stem cells transfected with reactive oxygen species-responsive polyplexes for effective treatment of ischemic stroke. Adv. Mater. 2019, 31, 1807591.

4. Xulei Qin,† Haodong Chen,† Huaxiao Yang,† Haodi Wu, Xin Zhao, Huiyuan Wang, Tony Chour, Evgenios Neofytou, Dan Ding, Heike Daldrup-Link, Sarah C. Heilshorn, Kai Li,* Joseph C. Wu.* Photoacoustic imaging of embryonic stem cell-derived cardiomyocytes in living hearts with ultrasensitive semiconducting polymer nanoparticles. Adv. Funct. Mater. 2018, 28, 1704939 (†contributed equally).

5. Heqi Gao, Xiaoyan Zhang, Chao Chen, Kai Li,* Dan Ding.* Unity makes strength: how aggregation-induced emission luminogens advance the biomedical field. Adv. Biosys. 2018, 2, 1800074 (Invited Review).

6. Kai Li, † Carmel T. Chan, † Hossein Nejadnik, † Olga D. Lenkov, Cody Wolterman, Ramasamy Paulmurugan, Huaxiao Yang, Sanjiv Sam Gambhir, Heike E. Daldrup-Link. Ferumoxytol-based dual-modality imaging probe for detection of stem cell transplant rejection. Nanotheranostics 2018, 2, 306-319 (†contributed equally).

7. Xiang Ni, Shaorui Jia, Xingchen Duan, Dan Ding,* Kai Li.* Fluorescent nanoparticles for noninvasive stem cell tracking in regenerative medicine. J. Biomed. Nanotechnol. 2018, 14, 240-256 (Invited Review).

8. Kai Li,* Hossein Nejadnik, Heike E. Daldrup-Link.* Next generation superparamagnetic iron oxide nanoparticles for cancer theranostics. Drug Discov. Today 2017, 22, 1421-1429 (Invited Review).

9. Guorui Jin, Jun Li, Kai Li.* Photosensitive semiconducting polymer-incorporated nanofibers for promoting the regeneration of skin wound. Mater. Sci. Eng. C 2017, 70, 1176-1181.

10. Suchismita Mohanty, Zixin Chen, Kai Li, Goreti Ribeiro Morais, Jessica Klockow, Ketan Yerneni, Laura Pisani, Frederick T. Chin, Siddhartha Mitra, Samuel Cheshier, Edwin Chang, Sanjiv Sam Gambhir, Jianghong Rao, Paul M. Loadman, Robert A. Falconer, Heike E. Daldrup-Link. A novel theranostic strategy for MMP-14 expressing glioblastomas impacts survival. Mol. Cancer Ther. 2017, 16, 1909-1921.

11. Hossein Nejadnik,† Seyedmeghdad Taghavigarmestani,† Steven Madsen, Kai Li, Saeid Zanganeh, Phillip Yang, Morteza Mahmoudi, Heike E. Daldrup-Link. The protein corona around nanoparticles facilitates stem cell labeling for clinical MRI. Radiology 2017, DOI: 10.1148/radiol.2017170130 (†contributed equally).

12. Guorui Jin, Guangxue Feng, Wei Qin, Ben Zhong Tang, Bin Liu,* Kai Li.* Multifunctional organic nanoparticles with aggregation-induced emission (AIE) characteristics for targeted photodynamic therapy and RNA interference therapy. Chem. Commun. 2016, 52, 2752-2755.

13. Shengjie Peng, Guorui Jin, Linlin Li, Kai Li, Madhavi Srinivasan, Seeram Ramakrishna, Jun Chen. Multi-functional electrospun nanofibres for advances in tissue regeneration, energy conversion & storage, and water treatment. Chem. Soc. Rev. 2016, 45, 1225-1241.

14. Guorui Jin, Duo Mao, Pingqiang Cai, Rongrong Liu, Nikodem Tomczak, Jie Liu, Xiaodong Chen, Deling Kong, Dan Ding,* Bin Liu,* Kai Li.* Conjugated polymer nanodots as ultrastable long-term trackers to understand mesenchymal stem cell therapy in skin regeneration. Adv. Funct. Mater. 2015, 25, 4263-4273 (Frontispiece Story).

15. Jie Liu, Kai Li,* Bin Liu.* Far-red/near-infrared conjugated polymer nanoparticles for long-term in-situ monitoring of liver tumor growth. Adv. Sci. 2015, 2, 1500008.

16. Ghayathri Balasundaram, Chris Jun Hui Ho, Kai Li, Wouter Driessen, U. S. Dinish, Chi Lok Wong, Vasilis Ntziachristos, Bin Liu, Malini Olivo. Molecular photoacoustic imaging of breast cancer using an actively targeted conjugated polymer. Inter. J. Nanomedicine 2015, 10, 387-397.

17. Dan Kai, Zhi Wei Low, Sing Shy Liow, Anis Abdul Karim, Hongye Ye, Guorui Jin, Kai Li, Xian Jun Loh. Development of lignin supramolecular hydrogels with mechanically responsive and self-healing properties. ACS Sustain. Chem. Eng. 2015, 3, 2160-2169.

18. Lu Peng, Meng Gao, Xiaolei Cai, Ruoyu Zhang, Kai Li, Guangxue Feng, Aijun Tong, Bin Liu. A fluorescent light-up probe based on AIE and ESIPT processes for beta-galactosidase activity detection and visualization in living cells. J. Mater. Chem. B 2015, 3, 9168-9172.

19. Kai Li, Bin Liu. Polymer-encapsulated organic nanoparticles for fluorescence and photoacoustic imaging. Chem. Soc. Rev. 2014, 43, 6570-6597.

20. Dan Ding,† Duo Mao,† Kai Li,† Xiaomin Wang, Wei Qin, Rongrong Liu, David Shunzhong Chiam, Nikodem Tomczak, Zhimou Yang, Ben Zhong Tang, Deling Kong, Bin Liu. Precise and long-term tracking of adipose-derived stem cells and their regenerative capacity via superb bright and stable organic nanodots. ACS Nano 2014, 8, 12620-12631 (†contributed equally).

21. Guorui Jin, Kai Li.* The electrically conductive scaffold as the skeleton of stem cell niche in regenerative medicine. Mater. Sci. Eng. C 2014, 45, 671-681 (Invited Review).

22. Kai Li,† Mie Yamamoto,† Su Jing Chan, Mun Yee Chiam, Wei Qin, Peter Tsun Hon Wong, Evelyn King Fai Yim, Ben Zhong Tang, Bin Liu. Organic nanoparticles with aggregation-induced emission for tracking bone marrow stromal cells in the rat ischemic stroke model. Chem. Commun. 2014, 50, 15136-15139 (Cover Story, †contributed equally).

23. Wei Qin,† Kai Li,† Guangxue Feng, Min Li, Zhiyong Yang, Bin Liu, Ben Zhong Tang. Bright and photostable organic fluorescent dots with aggregation-induced emission characteristics for noninvasive long-term cell imaging. Adv. Funct. Mater. 2014, 24, 635-643 (†contributed equally).

24. Guangxue Feng,† Kai Li,† Jie Liu, Dan Ding, Bin Liu. Bright single-chain conjugated polymer dots embedded nanoparticles for long-term cell tracing and imaging. Small 2014, 10, 1212-1219 (†contributed equally).

25. Junlong Geng, Kai Li, Wei Qin, Ben Zhong Tang, Bin Liu. Red-emissive chemiluminescent nanoparticles with aggregation-induced emission characteristics for in vivo hydrogen peroxide imaging. Part. Part. Syst. Charact. 2014, 31, 1238-1243.

26. Youyong Yuan, Dan Ding, Kai Li, Jie Liu, Bin Liu. Tumor-responsive fluorescent light-up probe based on gold nanoparticle/conjugated polyelectrolyte hybrid. Small 2014, 11, 1967-1975. (Cover Story)

27. Zibiao Li, Beng H. Tan, Guorui Jin, Kai Li, Chaobin He. Design of polyhedral oligomeric silsesquioxane (POSS) based thermo-responsive amphiphilic hybrid copolymers for thermally denatured protein protection applications. Poly. Chem. 2014, 5, 6740-6753.

28. Guangxue Feng, Dan Ding, Kai Li, Jie Liu, Bin Liu. Reversible photoswitching conjugated polymer nanoparticles for cell and ex vivo tumor imaging. Nanoscale 2014, 6, 4141-4147.

29. Kai Li, Wei Qin, Dan Ding, Nikodem Tomczak, Junlong Geng, Rongrong Liu, Jianzhao Liu, Xinhai Zhang, Hongyu Liu, Bin Liu, Ben Zhong Tang. Photostable fluorescent organic dots with aggregation-induced emission (AIE dots) for noninvasive long-term cell tracing. Sci. Rep. 2013, 3, 1150 (Highlighted by Nature News).

30. Kai Li, Dan Ding, Prashant Chandrasekharan, Wei Qin, Chang-Tong Yang, Ben Zhong Tang, Bin Liu. Gadolinium-functionalized aggregation-induced emission dots as dual-modality probes for cancer metastasis study. Adv. Healthcare Mater. 2013, 2, 1600-1605.

31. Kai Li, Zhenshu Zhu, Zujin Zhao, Nikodem Tomczak, Pingqiang Cai, Rongrong Liu, Jie Liu, Wei Qin, Yong Hu, Xiaodong Chen, Ben Zhong Tang, Bin Liu. Organic dots with aggregation-induced emission (AIE dots) characteristics for dual-color cell tracing. Chem. Mater. 2013, 25, 4181-4187.

32. Kai Li, Dan Ding, QiuLi Zhao, JingZhi Sun, B. Z. Tang, B. Liu. Biocompatible organic dots with aggregation-induced emission for in vitro and in vivo fluorescence imaging. Sci. China Chem. 2013, 56, 1228-1233.

33. Dan Ding, Kai Li, Bin Liu, Ben Zhong Tang. Bioprobes based on AIE fluorogens. Acc. Chem. Res. 2013, 46, 2441-2453.

34. Jing Liang, Kai Li, Bin Liu. Visual sensing with conjugated polyelectrolytes. Chem. Sci. 2013, 4, 1377-1394 (Invited Review).

35. Jie Liu, Kai Li, Junlong Geng, Li Zhou. Prashant Chandrasekharan, Chang-Tong Yang, Bin Liu. Single molecular hyperbranched nanoprobes for fluorescence and magnetic resonance dual modal imaging. Poly. Chem. 2013, 4, 1517-1524.

36. Junlong Geng, Kai Li, Wei Qin, Lin Ma, Gagik G. Gurzadyan, Ben Zhong Tang, Bin Liu. Eccentric loading of fluorogen with aggregation-induced emission in PLGA matrix increases nanoparticle fluorescence quantum yield for targeted cellular imaging. Small 2013, 9, 2012-2019.

37. Dan Ding, Kai Li, Wei Qin, Ruoyu Zhan, Yong Hu, Jianzhao Liu, Ben Zhong Tang, Bin Liu. Conjugated polymer amplified far-red/near-infrared fluorescence from nanoparticles with aggregation-induced emission characteristics for targeted in vivo imaging. Adv. Health. Mater. 2013, 2, 500-507 (Cover Story).

38. Dan Ding, Jie Liu, Guangxue Feng, Kai Li, Yong Hu, Bin Liu. Bright far-red/near-infrared conjugated polymer nanoparticles for in vivo bioimaging. Small 2013, 9, 3093-3102.

39. Kai Li, Dan Ding, Da Huo, Kan-Yi Pu, Ngo Nguyen Phuong Thao, Yong Hu, Zhi Li, Bin Liu. Conjugated polymer based nanoparticles as dual-modal probes for targeted in vivo fluorescence and magnetic resonance imaging. Adv. Funct. Mater. 2012, 22, 3107-3115.

40. Kai Li, Bin Liu. Polymer encapsulated conjugated polymer nanoparticles for fluorescence bioimaging. J. Mater. Chem. 2012, 22, 1257-1264.

41. Junlong Geng,† Kai Li,† Dan Ding, Xinhai Zhang, Wei Qin, Jianzhao Liu, Ben Zhong Tang, Bin Liu. Lipid-PEG-folate encapsulated nanoparticles with aggregation induced emission characteristics: cellular uptake mechanism and two-photon fluorescence imaging. Small 2012, 8, 3655-3663 (†contributed equally).

42. Qiuli Zhao,† Kai Li,† Sijie Chen, Anjun Qin, Dan Ding, Shuang Zhang, Yi Liu, Bin Liu, Jing Zhi Sun, Ben Zhong Tang. Aggregation-induced red-NIR emission organic nanoparticles as effective and photostable fluorescent probes for bioimaging. J. Mater. Chem. 2012, 22, 15128-15135 (†contributed equally).

43. Junlong Geng, Kai Li, Kan-Yi Pu, Dan Ding, Bin Liu. Conjugated polymer and gold nanoparticle co-loaded PLGA nanocomposites with eccentric internal nanostructure for dual-modal targeted cellular imaging. Small 2012, 15, 2421-2429.

44. Jing Liang, Kai Li, Gagik G. Gurzadyan, Xianmao Lu, Bin Liu. Silver nanocube-enhanced far-red/near-infrared fluorescence of conjugated polyelectrolyte for cellular imaging. Langmuir 2012, 28, 11302-11309.

45. Dan Ding, Guan Wang, Jianzhao Liu, Kai Li, Kan-Yi Pu, Yong Hu, Jason C. Y. Ng, Ben Zhong Tang, Bin Liu. Hyperbranched conjugated polyelectrolyte for dual-modality fluorescence and magnetic resonance cancer imaging. Small 2012, 8, 3523-3530.

46. Guan Wang, Xinhai Zhang, Junlong Geng, Kai Li, Dan Ding, Liping Cai, Yee-Hing Lai, Bin Liu. Glycosylated star-shaped conjugated oligomers for targeted two-photon fluorescence imaging. Chem. Eur. J. 2012, 18, 9705-9713.

47. Guan Wang, Junlong Geng, Xinhai Zhang, Liping Cai, Dan Ding, Kai Li, Long Wang, Yee-Hing Lai, Bin Liu. Pyrene-based water dispersible orange emitter for one- and two-photon fluorescence cellular imaging. Polym. Chem. 2012, 3, 2464-2470.

48. Kai Li, Yutao Liu, Kan-Yi Pu, Si-Shen Feng, Ruoyu Zhan, Bin Liu. Polyhedral oligomeric silsesquioxanes-containing conjugated polymer loaded PLGA nanoparticles with Trastuzumab (Herceptin) functionalization for HER2-positive cancer cell detection. Adv. Funct. Mater. 2011, 21, 287-294 (Inside Front Cover Story).

49. Kai Li, Kan-Yi Pu, Liping Cai, Bin Liu. Phalloidin-functionalized hyperbranched conjugated polyelectrolyte for filamentous actin imaging in living Hela cells. Chem. Mater. 2011, 23, 2113-2119.

50. Kai Li, Yihua Jiang, Dan Ding, Xinhai Zhang, Yutao Liu, Jianli Hua, Si-Shen Feng, Bin Liu. Folic acid-functionalized two-photon absorbing nanoparticles for targeted MCF-7 cancer cell imaging. Chem. Commun. 2011, 47, 7323-7325 (Back Cover Story).

51. Kai Li, Ruoyu Zhan, Si-Shen Feng, Bin Liu. Conjugated polymer loaded nanospheres with surface functionalization for simultaneous discrimination of different live cancer cells under single wavelength excitation. Anal. Chem. 2011, 83, 2125-2132.

52. Yu Mi,† Kai Li,† Yutao Liu, Kan-Yi Pu, Bin Liu, Si-Shen Feng. Herceptin functionalized polyhedral oligomeric silsesquioxane-conjugated oligomers-silica/iron oxide nanoparticles for tumor cell sorting and detection. Biomaterials 2011, 32, 8226-8233 (†contributed equally).

53. Dan Ding, Kai Li, Zhenshu Zhu, Kan-Yi Pu, Yong Hu, Xiqun Jiang, Bin Liu. Conjugated polyelectrolyte-cisplatin complex nanoparticles for simultaneous in vivo imaging and drug tracking. Nanoscale 2011, 3, 1997-2002.

54. Dan Ding, Kan-Yi Pu, Kai Li, Bin Liu. Conjugated oligoelectrolyte-polyhedral oligomeric Silsesquioxane 
loaded pH-responsive nanoparticles for targeted fluorescence imaging of cancer cell nucleus. Chem. Commun. 2011, 47, 9837-9839.

55. Kan-Yi Pu, Zhentao Luo, Kai Li, Jianping Xie, Bin Liu. Energy transfer between conjugated-oligoelectrolyte-substituted POSS and gold nanocluster for multicolor intracellular detection of mercury ion. J. Phys. Chem. C 2011, 115, 13069-13075.

56. Kan-Yi Pu, Jianbing Shi, Liping Cai, Kai Li, Bin Liu. Affibody-attached hyperbranched conjugated polyelectrolyte for targeted fluorescence imaging of HER2-positive cancer cell. Biomacromolecules 2011, 12, 2966-2974.

57. Guan Wang, Kan-Yi Pu, Xinhai Zhang, Kai Li, Long Wang, Liping Cai, Dan Ding, Yee-Hing Lai, Bin Liu. Star-shaped glycosylated conjugated oligomer for two-photon fluorescence imaging of live cells. Chem. Mater. 2011, 23, 4428-4434.

58. Kai Li, Bin Liu. Water-soluble conjugated polymers as the platform for protein sensors. Polym. Chem. 2010, 1, 252-259 (Cover Story).

59. Kan-Yi Pu,† Kai Li,† Bin Liu. Multicolor conjugate polyelectrolyte/peptide complexes as self-assembled nanoparticles for receptor-targeted cellular imaging. Chem. Mater. 2010, 22, 6736-6741 (†contributed equally).

60. Kan-Yi Pu, Kai Li, Bin Liu. Cationic oligofluorene-substituted polyhedral oligomeric silsesquioxane as light-harvesting unimolecular nanoparticle for fluorescence amplification in cellular imaging. Adv. Mater. 2010, 22, 643-646.

61. Kan-Yi Pu, Kai Li, Xinhai Zhang, Bin Liu. Conjugated oligoelectrolyte harnessed polyhedral oligomeric silsesquioxane as light-up hybrid nanodot for two-photon fluorescence imaging of cellular nucleus. Adv. Mater. 2010, 22, 4186-4189.

62. Kan-Yi Pu, Kai Li, Bin Liu. A molecular brush approach to enhance quantum yield and suppress nonspecific interactions of conjugated polyelectrolyte for targeted far-red/near-infrared fluorescence cell imaging. Adv. Funct. Mater. 2010, 20, 2770-2777.

63. Yutao Liu, Kai Li, Jie Pan, Bin Liu, Si-Shen Feng. Folic acid conjugated nanoparticles of mixed lipid monolayer shell and biodegradable polymer core for targeted delivery of docetaxel. Biomaterials 2010, 31, 330-338.

64. Yutao Liu, Kai Li, Bin Liu, Si-Shen Feng. A strategy for precision engineering of nanoparticles of biodegradable copolymers for quantitative control of targeted drug delivery. Biomaterials 2010, 31, 9145-9155.

65. Kai Li, Jie Pan, Si-Shen Feng, Arthur Wenqing Wu, Kan-Yi Pu, Yutao Liu, Bin Liu. Generic strategy of preparing fluorescent conjugated polymer-loaded poly(DL-lactide-co-glycolide) nanoparticles for targeted cell imaging. Adv. Funct. Mater. 2009, 19, 3535-3542 (Frontispiece Story).

66. Kai Li, Bin Liu. Conjugated polyelectrolyte amplified thiazole orange emission for label free sequence specific DNA detection with single nucleotide polymorphism selectivity. Anal. Chem. 2009, 81, 4099-4150.

67. Kan-Yi Pu, Kai Li, Jianbing Shi, Bin Liu. Fluorescent single-molecular core-shell nanospheres of hyperbranched conjugated polyelectrolyte for live-cell imaging. Chem. Mater. 2009, 21, 3816-3822.

News More

  • Prof. LI attended CBME 2018 and chaired the Nanomedicine subforum with oral report

    On 20-22nd Sep. 2018, Prof. LI attended CBME 2018 (Chinese Biomedical Engineering Academic Annual Meeting 2018) in Shenzhen, China. He chaired the subforum of Nanomedicine on 21st and gave oral speech with the title "Advanced Organic Nanoprobes for Stem Cell Tracking". 

    2018-09-22
  • Prof. LI attended Wiley-Nankai University Symposium on Biomaterials and Biological Systems in Tianjin with invited speech

    On 8th Sep. 2018, Prof. LI attended Wiley-Nankai University Symposium on Biomaterials and Biological Systems in Tianjin with the invited speech "Applications of Organic Nanoprobes in Long-time Stem Cell Tracking and Regenerative Medicine".

    2018-09-09

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The Department of Biomedical Engineering, Southern University of Science and Technology, seeks outstanding applicants for full-time tenure-track/tenured positions. The positions are open for both junior and senior-level applicants. While exceptional candidates in any area are welcome to apply, the primary focus for this search is in the areas of biomedical/medical imaging, bioMEMS, mechanomedicine, regenerative medicine, wearable devices/wireless monitoring, and biomedical data science. We are especially interested in individuals who can contribute to the excellence and diversity of our academic community. Further information of the department and facilities can be found at http://bme.sustc.edu.cn/.

An outstanding start-up package will be provided for the successful candidate. Applicants must have earned Ph.D. degree in biomedical engineering or a relevant field, and demonstrated excellent qualifications in research and education. Review of applications will begin immediately and continue until the positions are filled.

All applicants should submit the following documents to bmehr@sustech.edu.cn in PDF format: (1) a detailed resume, (2) a statement of research and teaching interests, (3) up to three representative publications, and (4) the names and contact information of at least three references.

Established in 2012, the Southern University of Science and Technology (SUSTech) is a public institution funded by the City of Shenzhen, , 17 min by high speed train from Hong Kong. Shenzhen is China's fast-growing city in the past two decades, having become the city with the highest per capita revenue from a fishing village. The city is the high-tech and manufacturing hub of China.

The Southern University of Science and Technology is a pioneer in higher education reform in China. The mission of the University is to become a globally recognized institution which emphasizes academic excellence and promotes innovation, creativity and entrepreneurship. The teaching language at SUSTech is bilingual, either English or Mandarin. According to Times Higher Education World University Ranking 2019, SUSTech ranked the 8th in mainland China.

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Contact Address

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Office Phone

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Email

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