Assistant Professor Department of Chemistry

Working Experience

Assistant Professor (10/2017 until now)

Department of Chemistry, Southern University of Technology (SUSTech)

Postdoc Researcher (03/2015-10/2017)

California Institute of Technology (Caltech)

Advisor: Prof. Peter B. Dervan

Research: Development of Pyrrole-Imidazole Polyamides as Transcription Inhibitors in the Treatment of Myotonic Dystrophy Type I (DM1)

Education

Ph.D., Organic Chemistry (01/2012-01/2015)

University of Pennsylvania

Advisor: Prof. Patrick J. Walsh

Thesis: Palladium-Catalyzed C-C Bond and C-S Bond Formation of Sulfoxides

M.S., Pharmaceutical Chemistry (09/2003-06/2006)

Ocean University of China, Qingdao, China.

Advisors: Profs. Qianqun Gu and Weiming Zhu

Thesis: Bioactive Secondary Metabolites of Fungi Isolated from Marine Alga

B.S., Pharmaceutics (09/2000-06/2003)

Ocean University of China, Qingdao, China.

Personal Profile

Research

1. DNA Chemical biology, anti-cancer drug development targeting

mismatched base pair of DNA, cytotoxicity evaluation in cell and in vivo.

2. Development of Pyrrole-Imidazole (Py-Im) polyamides as novel chemical

biology probe.

3. Novel methodology to construct high-valence sulfur-containing

compounds.

4. Novel “non-catalytic” methodology development.


Teaching

Chemical Biology (Bachelor/Graduate)


Publications Read More

Research in our group primarily spans into two major branches: chemical biology and organic methodology.

Our chemical biology projects are centered around DNA recognization. Non-Watson-Crick (mismatched) base pairs of DNA were considered to be the major cause of cancer, and the ratios among mismatched base pairs varied dramatically in different types of cancer cell lines. A family of synthetic peptides, namely Pyrrole-Imidazole Polyamides (PIP), is designed and synthesized to bind to mismatched base pairs in the ocean of Watson-Click base pairs with high affinity and specificity. The recognization of mismatched base pairs will be demonstrated on cancer cells and animal models in the long goal to developed bioactive peptides in the treatment of cancer.

The methodology research in our group will be focused on the combination of transition-metal catalysis and main group chemistry. We develop state-of-art methods to afford molecules with main-group-containing functional group, such sulfoxides, sulfones, and sulfoximines. We are also interested in developing modern “non-catalytic” transformations.

News More

  • Dervan院士夫妇来访

    Our academic grandparents Professor Peter B. Dervan and Jacqueline K. Barton from California Institute of Technology (Caltech) visited us on Sept. 14, 2018, and gave wonderful lectures entitled “Molecular Recognition of DNA: From Discovery to Oncology” and “DNA-Mediated Signaling”.

    2019-11-05
  • 孟庭庭同学参加暑期学校

    Our Ph.D. Ting-Ting Meng attended summer school of  The 8th Chiral Material Science in Lanzhou.

    2019-11-04
  • 欢送志媛,欢迎新同学

    We bid farewell party for Zhiyuan. Wish her have a successful career and happy life in the future!

    2019-11-04

Lab members Read More

Join us

We seek applications of postdoc researchers in the area of chemical biology, organic chemistry, medicinal chemistry and molecular biology. Please send your CV to jiatz@sustech.edu.cn.

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Contact Us

Contact Address

Room 507, Block 5, Innovation Park, 1088 Xueyuan Avenue, Shenzhen 518055, P.R. China

Office Phone

0755-88018376

Email

jiatz@sustech.edu.cn

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