Assistant Professor College of Science

Dr Ho Chun Loong is a Malaysian-born Assistant Professor under the Department of Biomedical Engineering at the Southern University of Science and Technology (SUSTech). His research focuses primarily on using synthetic biology and protein engineering to address various health and environmental issues. This includes establishing a platform where researchers could share their constructs and systematically amass these genetic constructs for protein engineering purposes.

Personal Profile

Dr Ho Chun Loong is a Malaysian-born Assistant Professor under the Department of Biomedical Engineering at the Southern University of Science and Technology (SUSTech). His research focuses primarily on using synthetic biology and protein engineering to address various health and environmental issues. This includes establishing a platform where researchers could share their constructs and systematically amass these genetic constructs for protein engineering purposes. In 2013, he received his Ph.D. in biochemistry from Nanyang Technological University of Singapore, under the guidance of Professor Liang Zhao-xun. He was engaged in the production of secondary metabolites by multimodular polyketide synthase and the design of proteins as biosensors to track the intrinsic levels of cyclic di-GMP, a signal molecule in bacteria. Subsequently, he worked as a postdoctoral researcher at the Center for Clinical and Technological Innovation in Synthetic Biology (SynCTI) of the National University of Singapore, focusing on the design of proteins that endow probiotics and symbiotic microorganisms with therapeutic functions. The research results have been published in the Nature Biomedical Engineering, Journal of American Chemistry Society, and ACS Synthetic Biology, etc. More than 150 references have been made and two patents have been applied for.

Education background: 
2003 – 2006 School of Science and Technology, Universiti Malaysia Sabah, Malaysia. Bachelor of Science (Hons) 
2008 – 2013 School of Biological Sciences, Nanyang Technological University, Singapore. Ph. D. in Biochemistry

Work experience: 
2018 – Present Assistant Professor, Department of Biomedical Engineering, 
Southern University of Science and Technology, China. 
2014 – 2018 Research Fellow and Cluster Leader of Therapeutic Research, 
Synthetic Biology for Clinical and Technological University, Yong Loo Lin School of 
Medicine, National University of Singapore, Singapore. 
2013 – 2013 Project Officer, School of Chemical and Biomedical Engineering, 
Nanyang Technological University, Singapore. 
2012 – 2013 Project Officer, School of Biological Science, Nanyang 
Technological University, Singapore.

Honours and Rewards: 
2008 NTU Research Scholarship (for PhD)

Research

Synthetic Biology, Protein Engineering


Teaching

Synthetic Biology (Graduate Student Level)


Publications Read More

1. Zhao Liu, Chun Loong HO. The Role of Proteins and Peptides in Human Microbiome Modulation. BAOJ Biotech, 2018, 4:036

2. Ho CL, Tan HQ, Chua KJ, Kang A, Lim KH, Ling KL, Yew WS, Thiery JP, Chang MW. Engineered commensal microbes for diet-mediated colorectalcancer chemoprevention. Nature Biomedical Engineering, 2018, 2, 27-37

3. Lubkowicz D*, Ho CL*, Lee YS, Chang MW. Reprogramming probiotic Lactobacillus reuteri as a biosensor for detecting Staphylococcal quorum sensing. ACS Synthetic Biology., 2018 DOI: 10.1021/acssynbio.8b00063 (* all authors contributed equally)

4. Hoang LP*, Ho CL*, Wong Adison*, Lee YS, Chang MW. Applying the designbuild-test paradigm in microbiome engineering. Current Opinion in Biotechnology, 2017, 48, 85-93 (* all authors contributed equally)

5. Ho CL, Hwang IY, Loh K, Chang MW. Matrix-immobilized yeast for large-scale production of recombinant human lactoferrin. MedChemComm, 2015, 6, 486-491

6. Ho CL, Chong KSJ, Akosua JO, Chuah MLC, Tan SM, Liang ZX. Visualizing the Perturbation of Cellular Cyclic di-GMP Levels in Bacterial Cells. Journal of the American Chemical Society, 2013, 135 (2), pp 566–569

7. Ho CL, Koh SL, Chuah MLC, Luo Z, Tan WJ, Low DKS, Liang ZX. Rational Design of Fluorescent Biosensor for cyclic di-GMP. Chembiochem: a European journal of chemical biology., 2011, 12(18):2753-8

8. Hwang IY, Tan MH, Koh E, Ho CL, Poh CL, Chang MW. Reprogramming Microbes to Be Pathogen-Seeking Killers. ACS Synthetic Biology., 2013, DOI: 10.1021/sb400077j

9. Rasouliha BH, Ling H, Ho CL, Chang MW. A predicted immunity protein confers resistance to pyocin S5 in a sensitive strain of Pseudomonas aeruginosa. Chembiochem: a European journal of chemical biology., 2013, DOI: 10.1002/cbic.201300410

10. Sun H, Ho CL, Ding F, Soehano I, Liu XW, Liang ZX. Synthesis of (R)-Mellein by a Partially Reducing Iterative Polyketide Synthase. Journal of the American Chemical Society. 2012; 134(29):11924-7.

11. Qi Y, Xu LH, Dong XM, Yau YH, Ho CL, Koh SL, Shochat SG, Chou SH, Tang K, Liang ZX. Functional Divergence of FimX in PilZ binding and Type IV Pili Regulation. Journal of bacteriology. 2012

12. Lim J, Kong R, Murugan E, Ho CL, Liang ZX. Solution Structures of the Acyl Carrier Protein Domain from the Highly Reducing Type I Iterative Polyketide Synthase CalE8. PloS one. 6(6):e20549.

News More

  • Master Graduates Recruitment Announcements 2020

    Dr Ho Chun Loong is a Malaysian-born Assistant Professor under the Department of Biomedical Engineering at the Southern University of Science and Technology (SUSTech). His research focuses primarily on using synthetic biology and protein engineering to address various health and environmental issues. This includes establishing a platform where researchers could share their constructs and systematically […]

    2019-09-16
  • Dr.Ho Chun Loong invited Professor Maybelle K. Go to give an academic lecture in the Department of BME

    On March 20, Dr.Ho Chun Loong invited Professor Maybelle K. Go to conduct an academic report entitled "Application of Synthetic Enzymes in Biological Targets" in Taizhou Building 324.  Professor Maybelle K. Go first introduced the concepts and principles of synthetase, as well as the mechanism of action of two enzymes, glycine decarboxylase and a heat-resistant […]

    2019-03-25
  • Dr.Ho Chun Loong invited Professor Lim Kaiyang to give an academic lecture in the Department of BME

    On January 17, Dr.Ho Chun Loong invited Professor Lim Kaiyang of Singapore Institute of Technology to conduct an academic report entitled "Search for the next generation antimicrobial agent: Antimicrobial Peptides and Propolis" in Taizhou Building 324. Teachers and students of our department attended the lecture. Lim Kaiyang received his Ph.D. in Chemistry and Biomolecular Engineering […]

    2019-03-24

Lab members Read More

Join us

Dr Ho Chun Loong is a Malaysian-born Assistant Professor under the Department of Biomedical Engineering at the Southern University of Science and Technology (SUSTech). His research focuses primarily on using synthetic biology and protein engineering to address various health and environmental issues. This includes establishing a platform where researchers could share their constructs and systematically amass these genetic constructs for protein engineering purposes. 

Postdoctoral recruitment:

Application conditions

1. Doctoral degree in biology, biochemistry, molecular biology, synthetic biology or tumor biology has been obtained or will be obtained in the near future.

2. Protein engineering, small animal model establishment and research background are preferred.

3. Responsible, practical, diligent, team-work spirit, with a certain degree of independent scientific research ability, and be able to guide students.

4. Giving priority to publishing SCI papers in 1-2 related fields, or publishing papers in top academic journals.

5. Good command of literature and English writing.

 

Treatment

1. Advanced scientific research facilities and strong research atmosphere.

2. The annual salary of RMB 270,000 (including the subsistence allowance of RMB 120,000 yuan per year (tax-free) supported by Shenzhen Municipal Finance) can be obtained after the examination and mid-term examination. In addition, the research group provides additional allowances and awards for outstanding postdoctoral students. Those who are especially outstanding can apply for the Principal Excellence Postdoctoral Award, with an annual salary of more than RMB 350,000 yuan.

3. Enjoy housing subsidy and social insurance such as medical treatment, endowment and work-related injuries; enjoy benefits such as holidays, meals, family planning incentives, high-temperature subsidies, free physical examination, etc.

4. The school provides each postdoctoral student with a biennial grant of RMB 25,000 for academic exchanges (including international conferences), and supports the application of research funds as project leaders.

5. After three years of working in Shenzhen, those who meet the reserve-level requirements of Shenzhen will receive a housing subsidy of RMB 800,000-1 million yuan, and can apply for RMB 300,000 yuan for research and start-up funds.

6. Overseas doctoral students or those with more than one year's study experience can apply for housing subsidy of RMB 1.6-2 million in Shenzhen for Peacock Project; RMB 2-5 million research start-up funds.

7. Excellent conditions, postdoctoral experience can also apply for research assistant professor position, annual salary of RMB 350,000.

 

Information

Please send the application materials (including resume, summary of published articles and academic achievements, work plan within one page) to: hejl@sustc.edu.cn. The headline of the email should be "XXX  Ho Chun Loong Research Group + Job" and the time of arrival should be indicated in the email. After strict screening, appointment will be arranged in time and personal information will be kept confidential.

Deadline: long term effective

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Contact Us

Contact Address

Taizhou Building 318, Southern University of Science and Technology, 1088 Xueyuan Blvd, Nanshan District, Shenzhen, China 518055

Office Phone

Email

hejl@sustc.edu.cn

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