Research Assistant Professor Academy for Advanced Interdisciplinary Sciences

2017 Southern University of Science and Technology Research Assistant Professor

2013 Max Delbrück Center for Molecular Medicine Postdoc

2013 Humboldt University of Berlin Ph.D. (Cell Biology)

2007 College of Pharmaceutical Sciences, Zhejiang University M.Sc. Med. (Pharmacology)

2005 Zhejiang University B.Sc. Med. (Pharmaceutical Sciences) & B.Sc. (Biotechnology)

Personal Profile

Research

1. Model the development of tumor formation with organoid culture, study the interplay between tumor-associated mutations, and identify biomarkers for tumor diagnostic.

2. Develop and use single cell sequencing techniques to study tumor heterogeneity and to identify key factors that drive different tumor phenotypes.

3. Use CRISPR-based genetic screen to discover key regulatory elements of cellular phenotype and cell signaling pathway.


Publications Read More

1. Zhu Q*, Fang L*, Heuberger J, Kranz A, Schipper J, Scheckenbach K, Vidal RO, Sunage-Franze DY, Müller M, Wulf-Goldenberg A, Sauer S, Birchmeier W. The Wnt-driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer. Cell Reports 2019 Jan 8;26(2):415-428.

2. Fang L, Zhu Q, Neuenschwander M, Specker E, Wulf-Goldenberg A, Birchmeier W. A small-molecule antagonist of the beta-catenin/TCF4 interaction blocks the self-renewal of cancer stem cells and suppresses tumorigenesis. Cancer Research 2016 Feb 15;76(4):891-901.

3. Holland JD, Gyorffy B, Vogel R, Eckert K, Valenti G, Fang L, Lohneis P, Elezkurtaj S, Ziebold U, Birchmeier W. Combined Wnt/beta-Catenin, Met, and CXCL12/CXCR4 Signals Characterize Basal Breast Cancer and Predict Disease Outcome. Cell Reports 2013;5(5):1214-27.

4. Wend P, Fang L, Zhu Q, Schipper JH, Loddenkemper C, Kosel F, Brinkmann V, Eckert K, Hindersin S, Holland JD, Lehr S, Kahn M, Ziebold U, Birchmeier W. Wnt/beta-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours. Embo J. 2013 Jul 17;32(14):1977-89.

Lab members Read More

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fangl@sustech.edu.cn

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