Chris Soon Heng Tan

Associate Professor Department of Chemistry

Chris graduated with B.Sc (2001) in Molecular Biology and a M.Sc (2005) in Computer Science from the National University of Singapore. He completed his PhD (2011) training at the University of Toronto, Canada with the late Prof. Tony Pawson. There, he made seminal contribution to our understanding of signaling network evolution related to organismal complexity and human diseases (Tan et al. Science 2009; Tan et al. Science Signaling 2009, Tan et al. Nature Method 2012). He subsequently moved to the Center of Molecular Medicine (CeMM) in Vienna, Austria and contributed to the development of a novel drug target deconvolution technology (Huber et al., Nature Method 2015) based on Cellular Thermal Shift Assay (CETSA). He was invited to join Institute of Molecular & Cell Biology (IMCB), A*STAR in 2015 by the inventor of CETSA, Prof. Pär Nordlund, and invented the first system-wide method for studying the dynamic of protein complexes directly from intact cells and tissues (Tan et al. Science 2018). Prior joining SUSTech, Chris led a research group in IMCB and the Bioinformatics Institute (BII), A*STAR, Singapore. Chris had published more than 30 articles in international journals and conferences, including first or corresponding authors in Science, Nature Methods, Science Signaling and Bioinformatics journals.

Personal Profile

 

Education

Sep 06 – Jul 11

Doctor of Philosophy, Department of Molecular Genetics, University of Toronto, Ontario, Canada

Jul 03 – Dec 05

Master of Science (Computer Science), School of Computing, National University of Singapore, Singapore

Jul 98 – May 01

Bachelor of Science, 2nd Upper Honors (Molecular Biology), School of Biological Sciences, National University of Singapore, Singapore

 

Research Experience                                                                                                  

Aug 19 - Present

Associate ProfessorDepartment of Chemistry, Southern University of Science & Technology, Shenzhen, China.

Apr 18 – Present

Joint Independent Fellow (Group Leader)Institute of Molecular and Cellular Biology & Bioinformatics Institutes, A*STAR, Singapore.

May 15 – Mar 18

Senior Research FellowInstitute of Molecular and Cellular Biology, A*STAR, Singapore. Mentor: Prof. Pär Nordlund

Jul 11 – Mar 15

Postdoctoral scientist, Research Center for Molecular Medicine (CeMM), Vienna, Austria. Mentor: Prof. Giulio Superti-Furga

Sep 06 – Jun 11

Ph.D. studentDepartment of Molecular Genetics, University of Toronto, Canada. Supervisors: Prof. Tony Pawson, Prof. Gary Bader & Prof. Rune Linding

Jul 03 – Dec 05

M.Sc. student, School of Computing, National University of Singapore, Singapore. Supervisor: Prof. See-Kiong Ng & Prof. Wing-Kin Sung.

Dec 01 – Aug 06

Research Engineer, Department of Knowledge Discovery & Data Mining, Institute for Infocomm Research, A*STAR, Singapore.

 

Grants

  1. Industry Alignment Fund (Pre-positioning): Toxicity Mode-of-Action Discovery (ToxMAD) Platform, May 2018 – April 2021, Co-PI, SGD1,102,417
  2. A*STAR-EDB Industry Alignment Fund: Study the Modes-of-Action (MoA) of Phthalates and Diketones using Toxicity MoA Discovery (ToxMAD) platform, Feb 2018 – Jan 2019, Co-PI, SGD110,000
  3. A*STAR Young Investigator Award: Thermal Proximity-based Co-Aggregation for System-level Monitoring of Protein Complexes in Primary and Non-engineered Cells, May 2016 – Apr 2019, PI, SGD195,000

Research

Network Biology

Systems Toxicology

Systems Pharmacology

Systems Chemical Biology

Computational Proteomics


Publications Read More

Chris had published more than 30 articles in international journals and conferences, including first or corresponding authors in Science, Nature Methods, Science Signaling and Bioinformatics journals. He has a H-index of 21 and his work had been highlighted in Science, Nature Genetics Review, Nature Methods, F1000Prime, Science Signaling, ACS Chemical Biology and Cell Systems. He had served as reviewer for Science, Nature Biotechnology, Nature Communication, and Bioinformatics.

News More

  • Science: Turning up the heat on protein interactions

    Deep data analytics drive the development of a technique that sheds light on drug action by monitoring the dynamics of thousands of protein complexes simultaneously within intact cells Protein-protein interactions are at the heart of all cellular functions and biological processes. These interactions are carefully regulated in space and time to meet the cell’s requirements […]

    2019-11-07
  • SUSTech wins Shenzhen “Talent Bole Award” for 4th consecutive year

    Earlier today, Southern University of Science and Technology was honored with its fourth consecutive “Talent Bole Award” from the city of Shenzhen, at a glittering ceremony at the Wuzhou Guest House in downtown Shenzhen. Shenzhen Municipal Party Committee Secretary Wang Weizhong Shenzhen Mayor Chen Rugui and other city leaders joined SUSTech President Chen Shiyi, Shenzhen […]

    2019-11-01
  • SUSTech ranked 7th in Nature Index Young Universities world rankings

    Earlier today, Nature Index posted its Young Universities 2019 supplement, ranking young universities that are 50 years old or less. In that list, Southern University of Science and Technology (SUSTech) was ranked 7th in the world. It was also ranked 6th in the world for chemistry, 14th for Earth and environmental sciences, and 11th in physical sciences. SUSTech has seen considerable growth in its fractional count […]

    2019-10-24

Lab members Read More

Join us

We are always looking for talented, self-motivated and creative individuals with interests in any of the following areas: Network Biology, Systems Toxicology, Systems Pharmacology, Systems Chemical Biology, Computational Proteomics. If you are interested in joining the group, please contact me directly.

 

Postdoctoral and Research Associate Positions are always available in our group each year.

Read More

Contact Us

Contact Address

430, Faculty Research Building 1, 1088 Xueyuan Road, Nanshan District, Shenzhen, Guangdong, China

Office Phone

0755-8801 8080

Email

christan@sustech.edu.cn

Copyright © 2018 All Rights Reserved.