Assistant Professor School of Sciences

Longzhen Cheng got her PhD from Fudan University in 2010. She did her postdoc in Dana-Farber Cancer Institute, Harvard medical school (2013-2016). Dr Cheng joined the Department of Biology, Southern University of Science and Technology (SUSTech) as an Assistant Professor in 2018. Her lab is interested in dissection of neural circuits for pain transmission and modulation. Ongoing projects: 1) Dissection of ascending and descending neural circuits for inflammatory and neuropathic pain; 2) Dissection of kappa opioid receptor-expressing neuron-mediated neural circuits for opioid induced hypersensitivity and morphine tolerance but not for opioid analgesia; 3) Dissection of neural circuits involved in craniofacial pain-induced body pain; 4) Dissection of descending neural circuits for chronic social isolation stress (SIS)-induced body pain; 5) Dissection of neural circuits for mirror-image pain (MIP). Her lab mainly uses genetic tools combined with behavior tests and electrophysiological recordings in the spinal cord to address these questions.

Personal Profile

Self-introduction
Dr. Longzhen Cheng got her PhD from Fudan University, supervised by Dr. Zhi-Qi Zhao. Then she worked as research associate in the Institute of Brain Science, Fudan University, mainly from 2009 to 2012. She did her postdoc at Harvard Medical School, in Dr. Qiufu Ma lab, from 2013 to 2016. She was selected as a member of “junior PI plan” from the Institute of Brain Science, Fudan University and established her own lab in October, 2016. She joined Southern University of Science and Technology in 2018. In recent 5 years, Dr. Cheng published several papers in peer-reviewed journals including Cell, Nature Neuroscience, etc.

Research Interests:
The dorsal spinal cord is the integrative center that processes and transmits a variety of somatic sensory modalities, such as pain, itch, touch and temperature. Our lab is interested in identification of spinal circuits for somatosensory information. Currently we are trying to dissect spinal mechanisms for chronic pain. Ongoing projects: 1) Identification of spinal circuits for chronic pain; 2) Gating mechanisms for chronic pain; 3) Synaptic plasticity of spinal dorsal horn neurons. We mainly use genetic tools combined with behavior tests and electrophysiological recordings in the spinal cord to address these questions.

Professional Experience:
02/2018 – present Assistant Professor, Southern University of Science and Technology, Shenzhen, China

02/2016 – 02/2018 Associate professor, Fudan University, Shanghai, China

02/2013 – 02/2016 Postdoctoral Fellow, Harvard Medical School Supervised by Dr. Qiufu Ma

04/2009 – 01/2013 Research associate, Fudan University, Shanghai, China

Educational Background:
08/2005 – 01/2009 Ph.D.: Neurobiology, Fudan University, Shanghai, China Supervised by Dr. Zhiqi Zhao

09/2002 – 07/2005 M.S.: Physiology, Wanan Medical College, Anhui, China Supervised by Dr. Mengya Wang

09/1997 – 07/2002 B.S.:Clinical medicine; Wannan Medical College, Anhui, China

Honors & Awards:
2013 Selected as a member of “Fudan University Excellent Plan”
2016 Selected as a member of “junior PI Plan” from Institute of Brain Science, Fudan University

 

Research

1. Dissection of ascending and descending neural circuits for inflammatory and neuropathic pain;

2. Dissection of kappa opioid receptor-expressing neuron-mediated neural circuits for opioid induced hypersensitivity and morphine tolerance but not for opioid analgesia;

3. Dissection of neural circuits involved in craniofacial pain-induced body pain;

4. Dissection of descending neural circuits for chronic social isolation stress (SIS)-induced body pain;

5. Dissection of neural circuits for mirror-image pain (MIP).


Teaching

1. Animal Physiology

2. Neurobiology


Publications Read More

1. Cheng L*, Duan B*, Huang T*, Zhang Y, Chen Y, Britz O, Garcia-Campmany L, Ren X, Vong L, Lowell BB, Goulding M, Wang Y#, Ma Q#. Identification of spinal circuits involved in touch-evoked dynamic mechanical pain. Nature Neuroscience 2017, 20(6):804-8014 (*Co-first author)

2. Duan B*, Cheng L*, Bourane S, Britz O, Padilla C, Garcia-Campmany L, Krashes M, Knowlton W, Velasquez T, Ren X, Ross SE, Lowell BB, Wang Y, Goulding M*, Ma Q*. Identification of spinal circuits transmitting and gating mechanical pain. Cell 2014, 159(6):1417-32 (*Co-first author)

3. Duan B#, Cheng L#, Ma Q#. Spinal circuits transmitting mechanical pain and itch. Neuroscience Bulletin 2017, Epub 2017 May 08 (#Co-corresponding author)

4. Bourane S*, Duan B*, Koch S, Dalet A, Britz A, Garcia-Campmany L, Kim E, Cheng L, Ghosh A, Ma Q#, Goulding M#. Gate control of mechanical itch by a subpopulation of spinal cord interneurons. Science 2015, 350(6260):550-4

News More

  • Gate Keepers: Study Identifies Spinal Cord Circuits for Mechanical Pain

    2019-11-04
  • Scientists indentify key cells in pain transmission system

    2019-11-04

Lab members Read More

Join us

We have one position open for postdoc. Please contact us if you are interested in:

chenglz@sustech.edu.cn

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Contact Us

Contact Address

1088 Xueyuan Rd., Nanshan District, Shenzhen, Guangdong, China 518055

Office Phone

+86-0755-88018489

Email

chenglz@sustech.edu.cn

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