Research Assistant Professor School of Medicine, Academy for Advanced Interdisciplinary Studies

Dr. Hemi Luan got his PhD from Hong Kong Baptist University, supervised by Prof. Zongwei Cai. He joined Southern University of Science and Technology in 2018. His work has yields about 12 first-author peer-reviewed papers with the total impact factors 47.896, citation times 1000 and H-index 14 according to the Google Scholar. Several major publications were on the journals of Mass Spectrom Rev, Bioinformatics, Gigascience, J Proteome Res, Analytica Chimica Acta and PNAS, etc. He has also obtained funding for two research projects, including NSFC and Education Science Program of Shenzhen.

Personal Profile

Research

Research interests are methodology development of mass spectrometry, pharmaco-metabolomics, and chemical biology. We develop a large-scale, high-throughput, non-targeted mass spectrometry based pharmaco-metabolomics methodology system, as well as specific analytical methods for targeting the gut flora related drugs/metabolites. Integration of mass spectrometry, pharmaco-metabolomics, and bioinformatics technologies seeks to study the drug/metabolite-driven pathophysiological metabolism, and discover the functional biomarkers and pharmacotherapeutic targets associated with chronic complex disorder. The main research results were the tryptophan-kynurenine metabolic reprogramming in the Parkinson's disease.

---------[Omics analysis & Software/algorithms]---------

-Biomedical mass spectrometry(Metabolomics、Lipidomics、Proteomics)

-Software/algorithms

(Bioinformatics 2020, Mass Spectrometry Reviews 2019, Anal Chim Acta. 2018, Journal of Chromatography B 2016, J Proteome Res 2014, Rapid Commun. Mass Spectrom. 2016)

---------[Software]---------

* statTarget

* CPVA

Project Web: https://github.com/13479776

---------[Functional small molecular: quantitative metabolism and regulation]---------

-Drug Targets

-Metabolism Defects

(Sci. Rep. 2015, Parkinsonism & Related Disorders 2015, Proc Natl Acad Sci U S A 2014, Sci. Rep. 2016)

---------[Metabolic Biology and AI modeling]---------

-Clinical diagnosis and Prognosis

-Precision treatment

-Drug resistance

( Gigascience 2015, Sci. Rep. 2015, J Proteome Res 2014, Biomarkers 2013)


Publications Read More

1. Luan, H.*, Jiang X., Lan Z., Ji F., Cai Z, Zhang W*. CPVA: a web-based metabolomic tool for chromatographic peak visualization and annotation. Bioinformatics 2020. (In Press, IF= 5.610, JCR Q1)

2. Luan, H., Xian Wang, Zongwei Cai*, Mass spectrometry-based metabolomics: Targeting the crosstalk between gut microbiota and brain in neurodegenerative disorders. Mass Spectrometry Reviews 2019, 38, 22-33 (IF = 8.887,ESI高被引(2019.11),引用次数27,JCR Q1)

3. Luan H.*, Ji F., Chen Y., Cai Z.*, statTarget: A streamlined tool for signal drift correction and interpretations of quantitative mass spectrometry-based omics data. Anal Chim Acta. 2018, 1036, 66-72. (IF = 5.977,引用次数26,JCQ Q1)

4. Luan, H., Chen, L., Ji, F., Cai, Z., PCI-GC-MS-MS approach for identification of non-amino organic acid and amino acid profiles. Journal of Chromatography B 2016, 1047, 180-184 (IF = 3.004,引用次数5,JCR Q2)

5. Luan, H.; Meng, N.; Liu, P.; Fu, J.; Chen, X.; Rao, W.; Jiang, H.; Xu, X.; Cai, Z.; Wang, J., Non-targeted metabolomics and lipidomics LC-MS data from maternal plasma of 180 healthy pregnant women. Gigascience 2015, 4, 16. (IF= 5.993,引用次数25,JCR Q1)

6. Luan, H.; Liu, L.; Tang, Z.; Mok, V.; Li, M.; Cai, Z., Elevated excretion of biopyrrin as a new marker for idiopathic Parkinson's disease, Parkinsonism & Related Disorders, 2015, 21, 1371-2 (IF = 3.926,,引用次数4,JCR Q1)

7. Luan, H.; Liu, L.; Tang, Z.; Zhang, M.; Chua, K.; Song, J.; Mok, V.; Li, M.; Cai, Z.,Comprehensive urinary metabolomic profiling and identification of potential noninvasive marker for idiopathic Parkinson's disease. Sci. Rep. 2015, 5, 13888. (IF = 3.998,引用次数64,包括被Nature Biotechnology正面引用,JCR Q2)

8. Luan, H.*; Meng, N.; Liu, P.; Feng, Q.; Lin, S.; Fu, J.; Davidson, R.; Chen, X.; Rao, W.; Chen, F.; Jiang, H.; Xu, X.; Cai, Z.; Wang, J., Pregnancy-induced metabolic phenotype variations in maternal plasma. J Proteome Res 2014, 13, (3), 1527-36. (IF = 4.074,引用次数67,JCR Q1)

9. Luan, H.; Liu, L. F.; Meng, N.; Tang, Z.; Chua, K. K.; Chen, L. L.; Song, J. X.; Mok, V. C.; Xie, L. X.; Li, M.; Cai, Z., LC-MS-Based Urinary Metabolite Signatures in Idiopathic Parkinson's Disease. J Proteome Res 2014. 14(1):467-78. (IF = 4.074,引用次数57,JCR Q1)

10. Luan, H.; Meng, N.; Fu, J.; Chen, X.; Xu, X.; Feng, Q.; Jiang, H.; Dai, J.; Yuan, X.; Lu, Y.; Roberts, A. A.; Luo, X.; Chen, M.; Xu, S.; Li, J.; Hamilton, C. J.; Fang, C.; Wang, J., Genome-wide transcriptome and antioxidant analyses on gamma-irradiated phases of deinococcus radiodurans R1. PLoS One 2014, 9, (1), e85649. (IF = 2.740,引用次数39,JCR Q2)

11. Luan, H.; Chen, X.; Zhong, S.; Yuan, X.; Meng, N.; Zhang, J.; Fu, J.; Xu, R.; Lee, C.; Song, S.; Jiang, H.; Xu, X., Serum metabolomics reveals lipid metabolism variation between coronary artery disease and congestive heart failure: a pilot study. Biomarkers 2013, 18, (4), 314-21. (IF = 2.070,引用次数21,JCR Q3)

12. Luan, H. M.; Wang, L. C.; Wu, H.; Jin, Y.; Ji, J., Antioxidant activities and antioxidative components in the surf clam, Mactra veneriformis. Nat Prod Res 2011, 25, (19), 1838-48. (IF = 2.158,引用次数24,JCR Q3)

13. 栾合密; 吴皓; 方东; 金燕, 蛤蜊化学成分及其生物活性研究进展. 中国海洋药物 2008, 27, (6), 57-61.

14. 栾合密; 王令充; 吴皓; 金燕; 陈士勇, 柱前衍生RP-HPLC法测定四角蛤蜊中牛磺酸的含量. 中药新药与临床药理 2010, 21, (2), 180-183.

合作文章

15. Hongzhi Zhao, Han Li, Yuanyuan Zheng, Zhu Lin, Jing Fang, Li Xiang, Shunqing Xu, Yanqiu Zhou, Hemi Luan, Wei Xia & Zongwei Cai. Association of altered serum acylcarnitine levels in early pregnancy and risk of gestational diabetes mellitus. Sci. China Chem. 2020, 63, 126–134. (IF = 6.356)

16. Ji F, Sreenivasmurthy SG, Wei J, Shao X, Luan H, Zhu L, Song J, Liu L, Li M, Cai Z. Study of BDE-47 induced Parkinson's disease-like metabolic changes in C57BL/6 mice by integrated metabolomic, lipidomic and proteomic analysis. J Hazard Mater. 2019, 15;378:120738. (IF = 9.038)

17. Zhao H, Li H, Chung ACK, Xiang L, Li X, Zheng Y, Luan H, Zhu L, Liu W, Peng Y, Zhao Y, Xu S, Li Y, Cai Z. Large-Scale Longitudinal Metabolomics Study Reveals Different Trimester-Specific Alterations of Metabolites in Relation to Gestational Diabetes Mellitus. J Proteome Res. 2019, 18(1):292-300. (IF = 4.074)

18. Shi Jingchun, Xiang Li, Luan Hemi, et al. The health concern of polychlorinated biphenyls (PCBs) in a notorious e-waste recycling site. Ecotoxicology and Environmental Safety, 2019, 186. (IF = 4.872)

19.

20. Ji Fenfen,Wei Juntong, Luan Hemi, et al. Study of metabolic disorders associated with BDE-47 exposure in Drosophila model by MS-based metabolomics. Ecotoxicology and Environmental Safety, 2019,184. (IF = 4.872)

21. Li Jiufeng, Xia Wei, Wu Chuansha, et al. Variations of phthalate exposure and metabolism over three trimesters. Environmental Pollution, 2019, 251:137-145. (IF = 6.792)

22. Xiang L, Zhang H, Wei J, Tian XY, Luan H, Li S, Zhao H, Cao G, Chung ACK, Yang C, Huang Y, Cai Z. Metabolomics studies on db/db diabetic mice in skeletal muscle reveal effective clearance of overloaded intermediates by exercise. Anal Chim Acta. 2018, 1037:130-139. (IF=5.977)

23. Ji, F., Luan, H., Huang, Y. et al. MS-Based Metabolomics for the Investigation of Neuro-Metabolic Changes Associated with BDE-47 Exposure in C57BL/6 Mice. J. Anal. Test. 2017, 1, 233–244.

24. Qin, C.; Yu, C.; Shen, Y.; Fang, X.; Chen, L.; Min, J.; …; Luan, H.; et. al, Whole-genome sequencing of cultivated and wild peppers provides insights into Capsicum domestication and specialization. Proc Natl Acad Sci U S A 2014, 111, (14), 5135-40. (IF=9.412)

25. Yang L., Li J., Lai J, Luan H., Cai Z., Wang Y., Zhao Y. and Wu Y., Placental transfer of perfluoroalkyl substances and associations with thyroid hormones: Beijing prenatal exposure study. Sci. Rep. 2016, 6, 21699. (IF = 3.998)

26. Wang, S., Chen, X., Luan, H., Gao, D., Lin, S., Cai, Z., Liu, J., Liu, H., and Jiang, Y. Matrix-assisted laser desorption/ionization mass spectrometry imaging of cell cultures for the lipidomic analysis of potential lipid markers in human breast cancer invasion. Rapid Commun. Mass Spectrom. 2016, 30: 533–42. (IF = 2.200)

27. Su L, Huang Y, Zhu Y, Xia L, Wang R, Xiao K, Wang H, Yan P, Wen B, Cao L, Meng N, Luan H, Liu C, Li X, Xie L. Discrimination of sepsis stage metabolic profiles with an LC/MS-MS-based metabolomics approach. BMJ Open Respir Res. 2014, 1(1):e000056. (IF = 3.998)

专利发表

28. Luan, H.; Zhang, J.; Cheng, L.; Kong, S.; Zhang, X.; Yang, H., Method for constructing DNA sequencing library and use thereof In WO Patent 2,012,079,490: 2012. (专利)

29. 成军;栾合密;黄颖瑜,膀胱癌患者尿液特异性代谢物谱、建立方法及用途. CN201110230207.4, 2012. (专利)

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    2020-03-19

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