Research Associate Professor

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Research

medicinal chemistry, pharmacology, small molecule drug discovery.


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代表文章:

1. Yingjun Li, # Kalyan Kumar Pasunooti, # Ruo-Jing Li, Wukun Liu, Sarah A. Head, Wei Q. Shi, Jun O. Liu. Novel Tetrazole-containing Analogs of Itraconazole as Potent Anti-angiogenic Agents with Reduced CYP3A4 Inhibition. Journal of Medicinal Chemistry. 2018, 61, 11158–11168.

2. Wei Yang,# Yingjun Li,# Yong Ai, Obinna Obianom, Dong Guo, Hong Yang, Srilatha Sakamuru, Menghang Xia, Yan Shu*, Fengtian Xue*. Pyrazole-Based Wnt/β-Catenin Signaling Pathway Inhibitors for the Treatment of Colorectal Cancer (CRC). Journal of Medicinal Chemistry. 2019, 62, 727-741.

3. Yingjun Li, Huimin Cheng, Zhang Zhang, Xiaoxi Zhuang, Jinfeng Luo, Huoyou Long, Yang Zhou, Yong Xu, Rana Taghipouran, Dan Li, Adam Patterson, Jeff Smaill, Zhengchao Tu, Donghai Wu, Xiaomei Ren, and Ke Ding. N-(3-Ethynyl-2,4-difluorophenyl) sulfonamide Derivatives as Selective RAF Inhibitors. ACS Medicinal Chemistry Letters. 2015, 6, 543-547.

4. Yingjun Li, Xiaoxi Zhuang, Lijie Peng, Ke Ding. Synthesis and Biological Evaluation of 2,7-diphenyl-4H-pyrido[1,2-a]-pyrimidin-4-ones as Transcriptional Function Suppressors of Estrogen-related Receptor a (ERRα). Scientia Sinica Chimic. 2015, 45, 968-978.

5. Zufeng Guo#, Zhiqiang Cheng#, Jingxin Wang#, Wukun Liu, Hanjing Peng, Yuefan Wang, A.V. Subba Rao, Ruojing Li, Xue Ying, Preethi Korangath, Maria Liberti, Yingjun Li, Yongmei Xie, Sam Y. Hong, Cordelia Schiene-Fischer, Gunter Fischer, Jason Locasale, Saraswati Sukumar, Heng Zhu, Jun O. Liu*. Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays, Angewandte Chemie International Edition, 2019, 58, 17158-17162.

6. Obinna N Obianom, Yong Ai, Yingjun Li, Wei Yang, Dong Guo, Hong Yang, Srilatha Sakamuru, Menghang Xia, Fengtian Xue, and Yan Shu. Triazole-Based Inhibitors of the Wnt/β-Catenin Signaling Pathway Improves Glucose and Lipid Metabolism in Diet-Induced Obese Mice. Journal of Medicinal Chemistry 2019, 62, 727–741

7. Yu Chang, Xiaoyun Lu, Marthandam Asokan Shibu, Yi-Bo Dai, Jinfeng Luo, Yan Zhang, Yingjun Li, Peng Zhao, Zhang Zhang, Yong Xu, Zheng-Chao Tu, Qing-Wen Zhang, Cai-Hong Yun, Chih-Yang Huang, and Ke Ding. Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl) benzene sulfonamides as Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors. Journal of Medicinal Chemistry. 2017, 60, 5927–5932.

8. Liao Jinxi, Huimin Cheng, Junting Wan, Panyu Chen, Yingjun Li, Ke Ding, Micky D. Tortorella, Zhengchao Tu, and Yanmei Zhang. Evaluation of Benzamide Derivatives as New Influenza A Nucleoprotein Inhibitors. Open Journal of Medicinal Chemistry. 2016, 43, 968-978.

9. Zhiling Zhou, Jifeng Deng, Yingjun Li, Yu Chang, Huimin Cheng. Determination of a novel B-Raf V600E and EGFR dual inhibitor in rat plasma by HPLC–MS/MS and its application in a pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis. 2016, 129, 142-147。

10. Chan Shingpan, Kun Han, Rong Qu, Linjiang Tong, Yingjun Li, Zhang Zhang, Huimin Cheng et al. 2, 4-Diarylamino-pyrimidines as kinase inhibitors co-targeting IGF1R and EGFR L858R/T790M. Bioorganic & medicinal chemistry letters. 2015, 25, 4277-4281.

11. Yupeng Li, Mengjie Shen, Zhang Zhang, Jinfeng Luo, Xiaofen Pan, Xiaoyun Lu, Huoyou Long, Donghai Wen, Fengxiang Zhang, Fang Leng, Yingjun Li, Zhengchao Tu, Xiaomei Ren, and Ke Ding. Design, Synthesis, and Biological Evaluation of 3-(1H-1,2,3-Triazol-1-yl)benzamide Derivatives as Potent Pan Bcr-Abl Inhibitors Including the Threonine315→Isoleucine315Mutant. Journal of Medicinal Chemistry. 2012, 55, 10033–10046.

12. Lijie Peng, Lei Duan, Xiaofeng Liu, Mengjie Shen, Yingjun Li, Jiajie Yan, Honglin Li, Ke Ding. Structure–activity Study on a Series of α-glutamic Acid Scaffold Based Compounds as New ADAMTS Inhibitors. Bioorganic & Medicinal Chemistry Letters. 2011, 21, 4457- 4461.

申请专利:

1. 丁克, 彭丽洁, 段磊, 沈梦婕, 李迎君, 严佳杰, 用作蛋白聚糖酶调节剂的化合物及其应用:中国. CN102276546B. 2014-6-25.

2. 丁克, 常少华, 朱孝峰, 李迎君, 邓蓉, 5-噻唑酰胺类化合物及其生物学应用:中国. CN101921268A. 2010-8-27.

3. 丁克, 程辉敏, 李迎君, 谈理, 王雪聪, 张章, 庄晓曦, 龙活尤, 5-芳基酚-2-烷基取代并咪唑类化合物和应用:中国. 201410069823.X. 2014-2-27.

4. 丁克, 李迎君, 程辉敏, 任小梅, 张章, 庄晓曦, 龙活尤, 涂正超, 磺酰胺基芳基炔类化合物及其用途:中国. 201410753013.6. 2014-12-9.

5. Jun Liu, Yingjun Li, Kalyan Kumar, Wukun Liu, Wei Shi, Rojing Li, and Sarah Head. Itraconazole Analogs and Use Thereof. The United States Application Serial No.: 62/742,046. 2018-10-5.

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Contact Address

1088 Xueyuan Blvd., Nanshan District, Shenzhen, Guangdong

Office Phone

0755-88018344

Email

liyj@sustech.edu.cn

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