Research Associate Professor College of Science

Dr. Sisi Li received her PhD from Fudan University in 2013 and joined Dinshaw J. Patel’s lab in MSKCC to study the x-ray crystallography, with the emphasis on epigenetic regulators. She joined SUSTech in 2016, now she is a research associate professor in biology department.

Personal Profile

Research


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1. Wu B#, Zhang D#, Nie H#, Shen S, Li Y, Li S*. Structure of Arabidopsis thaliana N6-methyl-AMP deaminase ADAL with bound GMP and IMP and implications for N6-methyl-AMP recognition. RNA Biol. 2019; 16: 1504-1512

2. Yang Z, Qiu Q, Chen W, Jia B, Chen X, Hu H, He K, Deng X, Li S, Tao WA, Cao X*, Du J*. Structure of the Arabidopsis JMJ14-H3K4me3 Complex Provides Insight into the Substrate Specificity of KDM5 Subfamily Histone Demethylases. Plant Cell. 2018; 30: 167-177.

3. Zheng S, Hu H, Ren H, Yang Z, Qiu Q, Qi W, Liu X, Chen X, Cui X, Li S, Zhou B, Sun D, Cao X, Du J. The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor. Nat Commun. 2019; 10: 1303

4. Li X, Harris CJ, Zhong Z, Chen W, Liu R, Jia B, Wang Z, Li S, Jacobsen SE*, Du J*. Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context biased non-CG DNA methylation. PNAS. 2018; 115: E8793-E8802

5. Yang Z, Qiu Q, Chen W, Jia B, Chen X, Hu H, He K, Deng X, Li S, Tao WA, Cao X*, Du J*. Structure of the Arabidopsis JMJ14-H3K4me3 Complex Provides Insight into the Substrate Specificity of KDM5 Subfamily Histone Demethylases. Plant Cell. 2018; 30: 167-177.

6. Li S#, Yen L#, Pastor WA, Johnston JB, Du J, Shew CJ, Liu W, Ho J, Stender B, Clark AT, Burlingame AL, Daxinger L, Patel DJ and Jacobsen SE. Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin. PNAS. 2016, 113: E5108-16. (# co-first author)

7. Höfer K#, Li S#, Abele F, Frindert J, Schlotthauer J, Grawenhoff J, Du J, Patel DJ and Jäschke A. Structure and function of the bacterial decapping enzyme NudC. Nat Chem Biol. 2016, 12: 730-4. (# co-first author)

8. Chen YC, Stuwe E, Luo Y, Ninova M, Le Thomas A, Rozhavskaya E, Li S, Vempati S, Laver JD, Patel DJ, Smibert CA, Lipshitz HD, Toth KF and Aravin AA. Cutoff suppresses RNA polymerase II termination to ensure expression of piRNA precursors. Mol Cell. 2016, 63: 97-109.

9. Shi X, Ran Z, Li S, Yin J and Zhong J. The Effect of MicroRNA bantam on Baculovirus AcMNPV Infection in Vitro and in Vivo. Viruses. 2016, 8: 136.

10. Li S, Patel DJ. Drosha and Dicer: Slicers cut from the same cloth. Cell Res. 2016 26: 511-2.

11. Li S, Yang Z, Du X, Gozani O, Jacobsen SE, Patel DJ and Du J. Structural basis for the unique combinatorial readout of unmodified H3 tail by Arabidopsis ORC1b BAH-PHD cassette. Structure. 2016 24: 486-94.

12. Webster A, Li S, Hur JK, Wachsmuth M, Bois JS, Perkins EM, Patel DJ, Aravin AA. Aub and Ago3 Are Recruited to Nuage through Two Mechanisms to Form a Ping-Pong Complex Assembled by Krimper. Mol Cell. 2015 59: 564-75.

13. Kim B, Ha M, Loeff L, Chang H, Simanshu DK, Li S, Fareh M, Patel DJ, Joo C, Kim VN. TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms. EMBO J. 2015 34:1801-15.

14. Le Thomas A, Stuwe E, Li S, Du J, Marinov G, Rozhkov N, Chen YC, Luo Y, Sachidanandam R, Toth KF, Patel D, Aravin AA. Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing. Genes Dev. 2014 28:1667-80.

15. Du J, Johnson LM, Groth M, Feng S, Hale CJ, Li S, Vashisht AA, Gallego-Bartolome J, Wohlschlegel JA, Patel DJ, Jacobsen SE. Mechanism of DNA methylation-directed histone methylation by KRYPTONITE. Mol Cell. 2014 55: 495-504.

16. Li B, Li S, Yin J, Zhong J. Identification and characterization of the Spodoptera Su(var)3-9 histone H3K9 trimethyltransferase and its effect in AcMNPV infection. PLoS One. 2013 8: e69442

17. Li S, Du J, Yang H, Yin J, Ding J, Zhong J. Functional and structural characterization of DNMT2 from Spodoptera frugiperda. J.Mol.Cell Biol. 2013 5: 64-6.

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Contact Address

Rm 202,Block B Biology Building,SUSTech

Office Phone

0755-88018446

Email

liss6@sustech.edu.cn

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