Associate Professor Department of Biology

Dr. Ji obtained his Doctor of Science degree (equivalent to Ph.D.) from Peking University in 2003. He then visited Johns Hopkins University School of Medicine and Cornell University Weill Medical College for postdoctoral training and research. Dr. Ji has mainly focused on developmental neurobiology. He is primarily interested in elucidating mechanisms regulating neuronal development by different signal pathways including retrograde signals derived from target tissues of axon. He also made progresses on studying the roles of local protein synthesis in axons and mRNA modification during neuronal development.

Personal Profile

Research

Novel mechanisms regulating neural development and functions:

◆ mRNA modification

◆ Local mRNA translation in axons

◆ Retrograde signaling from axonal terminal to soma


Teaching

Neurobiology (Undergraduate)

Cellular and Molecular Neurobiology (Graduate)


Publications Read More

Selected publications(*corresponding author;#co-first authors)

1. Mengru Zhuang, Xinbei Li, Junda Zhu, Jian Zhang, Fugui Niu, Fanghao Liang, Mengxian Chen, Duo Li, Peng Han, Sheng-Jian Ji*. The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression. Nucleic Acids Research 2019, 47(9): 4765-4777. Published online Mar 7, 2019.

2. Jun Yu#, Mengxian Chen#, Haijiao Huang#, Junda Zhu, Huixue Song, Jian Zhu, Jaewon Park, Sheng-Jian Ji*. Dynamic m6A modification regulates local translation of mRNA in axons. Nucleic Acids Research 2018, 46(3): 1412-1423. Published online Nov 23, 2017.

3. Sheng-Jian Ji, Samie R. Jaffrey*. Axonal transcription factors: Novel regulators of growth cone-to-nucleus signaling. Developmental Neurobiology 2014, 74(3): 245-258.

4. Dilek Colak, Sheng-Jian Ji, Bo Torben Porse, Samie R. Jaffrey*. Regulation of axon guidance by nonsense-mediated mRNA decay. Cell 2013, 153(6): 1252-1265.

5. Sheng-Jian Ji, Samie R. Jaffrey*. Intra-axonal translation of SMAD1/5/8 mediates retrograde regulation of trigeminal ganglia subtype specification. Neuron 2012, 74(1): 95-107.

6. Breset A. Walker#, Sheng-Jian Ji#, Samie R. Jaffrey*. Intra-axonal translation of RhoA promotes axon growth inhibition by CSPG. Journal of Neuroscience 2012, 32(41): 14442-14447.

7. Sheng-Jian Ji, Goran Periz, Shanthini Sockanathan*. Nolz1 is induced by retinoid signals and controls motoneuron subtype identity through distinct repressor activities. Development 2009, 136 (2): 231-240.

8. Sheng-Jian Ji#, Binquan Zhuang#, Crystal Falco, André Schneider, Karin Schuster-Gossler, Achim Gossler, Shanthini Sockanathan*. Mesodermal and neuronal retinoids regulate the induction and maintenance of forelimb spinal motor neuron subtype identity. Developmental Biology 2006, 297(1): 249-261.

9. Sheng-Jian Ji, Ying-Chun Lu, Jian-Xun Feng, Gang Wei, Jun Li, Yong-Hui Shi, Qiang Fu, Di Liu, Jing-Chu Luo, Yu-Xian Zhu*. Isolation and analyses of genes preferentially expressed during early cotton fiber development by subtractive PCR and cDNA array. Nucleic Acids Research 2003, 31(10): 2534-2543.

10. Sheng Jian Ji, Feng Liu, Er Qiu Li, Yu Xian Zhu*. Recombinant scorpion insectotoxin AaIT kills specifically insect cells but not human cells. Cell Research 2002, 12(2): 143-150.

11. Shengjian Ji, Yingchun Lu, Jun Li, Gang Wei, Xiujuan Liang, Yuxian Zhu*. A b-tubulin-like cDNA expressed specifically in elongating cotton fibers induces longitudinal growth of fission yeast. Biochemical and Biophysical Research Communications 2002, 296(5): 1245-1250.

News More

  • LIU Jianhui and LIN Xiaoyan passed their master thesis defenses. Congratulations!

    2020-06-03
  • The Graduation Story – Biology mentor guides undergraduates to excellence

    2020-05-20
  • Prof. Ji gave a talk at the 4th Sino-German Symposium on RNA biology

    2019-11-12

Lab members Read More

Join us

Currently we seek motivated candidates to apply for the postdoc and PhD fellowships in the lab. Please send your detalied CV (with complete education and publication records) to jisj#sustech.edu.cn.

 

Read More

Contact Us

Contact Address

Room 305, Research Building 1, Southern University of Science and Technology, No. 1088 Xueyuan Road, Nanshan District, Shenzhen, Guangdong,China

Office Phone

0755-88018498

Email

jisj@sustech.edu.cn

Copyright © 2018 All Rights Reserved.