Associate Professor Department of Biology

Dr. Wenfei Jin is an Associate Professor (PI) in Department of Biology in Southern University of Science and Technology (SUSTech). He has worked on population genetics and precision medicine related field since his Ph.D. program. He has published >30 research articles and book chapters, including first author and corresponding author articles on Nature, Nat Methods, Genome Res, AJHG and Genome Biol. He and his colleagues developed single cell DNase-seq that provides key regulatory information for precision medicine (Jin, et.al, 2015 Nature).

Dr. Wenfei Jin received his bachelor’s degree from Zhengzhou University in 2006. He received his Ph.D. in Computational biology from Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology (PICB) with Prof. Li Jin (CAS member) and Prof. Shuhua Xu in 2012. Dr. Jin completed his Postdoc Fellow in systems biology in National Institutes of Health (NIH) with Dr. Keji Zhao in 2017. Dr. Jin is the recipient of many honors and awards including Springer Theses, CAS Excellent Doctoral Dissertation and NHLBI Orloff Award. Dr. Jin is especially interested in promoting the applications of single cell sequencing in clinical diagnosis and medical consultation.

Dr. Jin is interested in 1) single cell sequencing and its applications in cancer biology; 2) bioinformatics and identifying genetic/epigenetic changes that drive oncogenesis; 3) developing cancer prediction and treatment model for precision medicine.

Personal Profile

Dr. Wenfei Jin is an Associate Professor (PI; PhD supervisor;Tenure Track) in Department of Biology in Southern University of Science and Technology (SUSTech). Dr. Jin received his bachelor's degree from Zhengzhou University in 2006. He received his Ph.D. in Computational biology from Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology (PICB) with Prof. Li Jin (CAS member) and Prof. Shuhua Xu in 2012. Dr. Jin completed his Postdoc Fellow in systems biology at National Institutes of Health (NIH) with Dr. Keji Zhao in 2017. He joined in Southern University of Science and Technology (SUSTech) in 2017. Dr. Jin works on population genetics and precision medicine related field since his Ph.D. program. He has published >20 research articles and book chapters, including first/co-fist author articles on Nature, AJHG, Genome Res, Genome Biol and HMG. Dr. Jin and his colleagues developed single cell DNase-seq (scDNase-seq) that could provide key regulatory information for precision medicine (Jin, et.al, 2015 Nature). Dr. Jin is the recipient of many honors and awards including Springer Theses, CAS Excellent Doctoral Dissertation and NHLBI Orloff Award. Dr. Jin is especially interested in promoting the applications of single cell sequencing in clinical diagnosis and medical consultation.

Research interests

Dr. Jin’s lab is interested in identifying genetic/epigenetic changes that drive oncogenesis, and developing disease risk prediction model for precision medicine. The long-term goal of the lab is to develop efficient personalized treatment for cancers based on patients’ genetic background. In near future, the lab will focus on investigating genetic/epigenetic heterogeneity and micro-evolution of cancer cells using single cell sequencing related technologies.

Professional Experience

Mar.2017-present        Associate Professor, Southern University of Science and Technology

Jan.2013-Mar.2017     Postdoc fellow, National Institutes of Health (NIH)                              

Mentor: Dr. Keji Zhao

Jan.2012-Dec.2012      Assistant researcher, Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology (PICB), SIBS, CAS

Education

Sept.2006-Dec.2011    Ph.D. in Computational Biology, PICB and University of Chinese Academies of Sciences

Supervisors: Prof. Felix Li Jin (CAS member) and Dr. Shuhua Xu

Feb.2006-April.2006   Intern, Institute of Biochemistry and Cell Biology, SIBS, CAS

Mentors: Prof. Mofang Liu and Prof. Enduo Wang (CAS member)

Sept.2001-July.2006    B.Sc. in Biotechnology, Zhengzhou University, China

Awards and Honors

2018    National level leading expert, Shenzhen

2018    Outstanding Advisor of College, Zhixin College, SUSTech

2017     Distinguished Scientist Award, NIH-CSSA

2016    Orloff innovation Awards, NHLBI, USA

2016     Fellows Award for Research Excellence (FARE), NIH, USA

2014    Springer Theses, Springer

2013    Excellent Doctoral Dissertation, Chinese Academy of Sciences

2012    First-author Awards, PICB                                                  

2012    Outstanding Graduate Award, University of Chinese Academy of Sciences

2012    SIBS-Eli Lilly Outstanding Ph.D. Thesis Awards, Eli Lilly

2011    Travel Awards, 12th International Congress of Human Genetics (ICHG)/61th ASHG

2011    Pfizer Awards, Shanghai Institutes for Biological Sciences

2010    Di’ao scholarship Awards, Chinese Academy of Sciences

Research

The long-term goal of Jin lab is developing precision diagnosis and treatment for cancers. Currently, our lab mainly works on designing single cell multi-omics approaches to address questions in development and medicine, particularly focus on:

1) Developing single cell sequencing to study tumor microenvironment and model tumor development

2) Investigating the cellular heterogeneity and its mechanism via single cell technology


Teaching

Courses:

Computational Biology

Bioinformatics

Genomics


Publications Read More

Selected Representative Publications (#equal contribution; * corresponding author)

14. Preprint at Research Square: Shen X#, Wang X#, Chen S, Liu H, Hong N, Jin W*. Reclassification of classic T cell subsets and identification of novel cell types by single-cell RNA sequencing.

13. Preprint: Yi G, Lin Y, Jin W*. Sequences Dimensionality-Reduction by K-mer Substring Space Sampling Enables Effective Resemblance-and Containment-Analysis for Large-Scale omics-data. bioRXiv, 2019, 729665. https://www.biorxiv.org/content/10.1101/729665v1

12. Qin P#, Pang Y#, Hou W#, Fu R#, Zhang Y#, Wang X#, Meng G, Liu Q, Zhu X, Hong N*, Cheng T* and Jin W* Integrated decoding hematopoiesis and leukemogenesis using single cell sequencing and its medical implication. Cell Discovery (Accepted) Available preprint: https://www.biorxiv.org/content/10.1101/2020.02.21.960401v1

11. Han Z, Cui K, Placek K, Hong N, Lin C, Chen W, Zhao K*, Jin W*, (2020) Diploid genome architecture revealed by multi-omic data of hybrid mice. Genome Res. Genome Res. 30:1097-1106.

10. Wang W, Ren G, Hong N*, Jin W*. (2019) Exploring the Changing Landscape of Cell-to-Cell Variation After CTCF Knockdown via Single Cell RNA-seq. BMC Genomics. 20:1015. doi: 10.1186/s12864-019-6379-5.

9. Lai B#, Tang Q# Jin W#, Hu G#, Wangsa D, Cui K, Stanton BZ, Ren G, Ding Y, Zhao M, Liu S, Song J, Ried T, Zhao K. (2018). Trac-looping measures genome structure and chromatin accessibility. Nat Methods. 15:741-747.

8. Lai B, Gao W, Cui K, Xie W, Tang Q, Jin W, Hu G, Ni B, Zhao K. (2018) Principles of nucleosome organization revealed by single-cell micrococcal nuclease sequencing. Nature. 562:281-285

7. Ren G#, Jin W#, Cui K, Rodrigez J, Hu G, Zhang Z, Larson DR, Zhao K. (2017). CTCF-Mediated Enhancer-Promoter Interaction Is a Critical Regulator of Cell-to-Cell Variation of Gene Expression. Mol Cell 67: 1049-1058.

6. Jin W#, Tang Q#, Wan M, Cui K, Zhang Y, Ren G, Ni B, Sklar J, Przytycka T, Childs R, Levens D, Zhao K. (2015) Genome-wide detection of DNase I hypersensitive sites in single cells and FFPE tissue samples. Nature. 528:142-146

5. Jin W, Li R, Zhou Y, Xu S. (2014) Distribution of ancestral chromosomal segments in admixed genomes and its implications for inferring population history and admixture mapping. Euro J Hum Genet. 22:930-937.

4. Kraushaar DC#, Jin W#, Maunakea A, Abraham B, Ha M, Zhao K. (2013) Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3. Genome Biol. 14:R121.

3. Jin W, Xu S, Wang H, Yu Y, Shen Y, Wu B, Jin L. (2012) Genome-wide detection of natural selection in African Americans pre- and post-admixture. Genome Res. 22:519-527.

2. Jin W, Wang S, Wang H, Jin L, Xu S. (2012) Exploring population admixture dynamics via empirical and simulated genome-wide distribution of ancestral chromosomal segments. Am J Hum Genet. 91:849-862.

1. Jin W, Qin P, Lou H, Jin L, Xu S. (2012) A systematic characterization of genes underlying both complex and Mendelian diseases. Hum Mol Genet. 21: 1611-1624.

News More

  • New insights found into genomic architecture by SUSTech scholars

    2020-08-17
  • SUSTech And NIH Scientists Developed Novel Method For Simultaneously Investigating Chromatin Interaction And Chromatin Accessibility

    2020-08-11

Lab members Read More

Join us

We are seeking highly motivated postdoctoral fellows, PhD students, graduate students and interns with interesting in single cell sequencing and precision medicine to join our lab. Dr. Wenfei Jin’s lab in the Southern University of Science and Technology is interested in 1) single cell sequencing and its applications in cancer biology; 2) identifying genetic/epigenetic changes that drive oncogenesis; 3) developing cancer prediction and treatment model for precision medicine. The long-term goal of the lab is to develop efficient personalized treatment for cancers based on patients’ genetic background. In near future, the lab will focus on investigating genetic/epigenetic heterogeneity and micro-evolution of cancer cells using single cell sequencing related technologies. The lab is well funded by multiple programs including "National Key R&D Program" and "National Science Foundation of China (NSFC)".

  1. Postdoc’s annual total salary usually is about 330,000 RMB(48,000 USD) per year,  (Applicants should have a track-record of high quality publications).
  2. Scholarship is highly competitive (about 100,000 RMB per year for PhD student; about 50,000 RMB per year for graduate student)
  3. Stipends for intern will depends on applicant’s performance.

Contact

If you are interested in joining Dr. Jin’s lab, please send your C.V. and the names of 2-3 references to Dr. Jin (jinwf@sustech.edu.cn). We look forward to hearing from you!

Read More

Contact Us

Contact Address

1088 Xueyuan Avenue # Faculty Research Building NO.1, Room 206

Office Phone

(+86) 0755-88018478

Email

jinwf@@sustech.edu.cn

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