Research Associate Professor College of Science, Department of Biology, Academy for Advanced Interdisciplinary Studies

2020 Southern University of Science and Technology Research Associate Professor

2017 Southern University of Science and Technology Research Assistant Professor

2013 Max Delbrück Center for Molecular Medicine Postdoc

2013 Humboldt University of Berlin Ph.D. (Cell Biology)

2007 College of Pharmaceutical Sciences, Zhejiang University M.Sc. Med. (Pharmacology)

2005 Zhejiang University B.Sc. Med. (Pharmaceutical Sciences) & B.Sc. (Biotechnology)

Personal Profile

Research

1. Study tumor heterogeneity using single-cell sequencing, aiming at identification of key transcription factors that drive tumor phenotype;

2. Identification of key factors that affect the EMT phenotype and the Wnt signaling in tumor cells using pooled CRISPR screen;

3. Modeling tumor development using organoid culture to study the crosstalk between different driver mutations;

4. Development of novel CRISPR-based genetic screening platforms for identification of modulators of different RNA posttranscriptional regulations;

5. Development of various techniques related to single-cell sequencing.


Publications Read More

1. YI, H.*, LI, G.*, LONG, Y., LIANG, W., CUI, H., ZHANG, B., TAN, Y., LI, Y., SHEN, L., DENG, D., TANG, Y., MAO, C., TIAN, S., CAI, Y., ZHU, Q., HU, Y. #, CHEN, W. # & FANG, L.# 2020. Integrative multi-omics analysis of a colon cancer cell line with heterogeneous Wnt activity revealed RUNX2 as an epigenetic regulator of EMT. Oncogene.

2. PRAKTIKNJO, S. D.*, OBERMAYER, B.*, ZHU, Q.*, FANG, L., LIU, H., QUINN, H., STOECKIUS, M., KOCKS, C., BIRCHMEIER, W. & RAJEWSKY, N. 2020. Tracing tumorigenesis in a solid tumor model at single-cell resolution. Nat Commun, 11, 991.

3. LI, Y.*, SCHAEFKE, B.*, ZOU, X., ZHANG, M., HEYD, F., SUN, W., ZHANG, B., LI, G., LIANG, W., HE, Y., ZHOU, J., LI, Y., FANG, L., HU, Y. & CHEN, W. 2020. Pan-tissue analysis of allelic alternative polyadenylation suggests widespread functional regulation. Mol Syst Biol, 16, e9367.

4. ZHU, Q.*, FANG, L.*, HEUBERGER, J., KRANZ, A., SCHIPPER, J., SCHECKENBACH, K., VIDAL, R. O., SUNAGA-FRANZE, D. Y., MULLER, M., WULF-GOLDENBERG, A., SAUER, S. & BIRCHMEIER, W. 2019. The Wnt-Driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer. Cell Rep, 26, 415-428 e5.

5. WANG, X.*, YOU, X.*, LANGER, J. D., HOU, J., RUPPRECHT, F., VLATKOVIC, I., QUEDENAU, C., TUSHEV, G., EPSTEIN, I., SCHAEFKE, B., SUN, W., FANG, L., LI, G., HU, Y., SCHUMAN, E. M. & CHEN, W. 2019. Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus. Nat Commun, 10, 5009.

6. QI, X. T., LI, Y. L., ZHANG, Y. Q., XU, T., LU, B., FANG, L., GAO, J. Q., YU, L. S., ZHU, D. F., YANG, B., HE, Q. J. & YING, M. D. 2019. KLF4 functions as an oncogene in promoting cancer stem cell-like characteristics in osteosarcoma cells. Acta Pharmacol Sin, 40, 546-555.

7. LAM, J. H.*, LI, Y.*, ZHU, L., UMAROV, R., JIANG, H., HELIOU, A., SHEONG, F. K., LIU, T., LONG, Y., LI, Y., FANG, L., ALTMAN, R. B., CHEN, W., HUANG, X. & GAO, X. 2019. A deep learning framework to predict binding preference of RNA constituents on protein surface. Nat Commun, 10, 4941.

8. CHEN, T.*, ZHANG, B.*, ZIEGENHALS, T., PRUSTY, A. B., FROHLER, S., GRIMM, C., HU, Y., SCHAEFKE, B., FANG, L., ZHANG, M., KRAEMER, N., KAINDL, A. M., FISCHER, U. & CHEN, W. 2019. A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing. PLoS Genet, 15, e1008460.

9. WENG, Q., WANG, J., WANG, J., WANG, J., SATTAR, F., ZHANG, Z., ZHENG, J., XU, Z., ZHAO, M., LIU, X., YANG, L., HAO, G., FANG, L., LU, Q. R., YANG, B. & HE, Q. 2018. Lenalidomide regulates CNS autoimmunity by promoting M2 macrophages polarization. Cell Death Dis, 9, 251.

10. SCHAEFKE, B.*, SUN, W.*, LI, Y. S.*, FANG, L. & CHEN, W. 2018. The evolution of posttranscriptional regulation. Wiley Interdiscip Rev RNA, 9, e1485.

11. FANG, L., ZHU, Q., NEUENSCHWANDER, M., SPECKER, E., WULF-GOLDENBERG, A., WEIS, W. I., VON KRIES, J. P. & BIRCHMEIER, W. 2016. A Small-Molecule Antagonist of the beta-Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis. Cancer Res, 76, 891-901.

12. WEND, P., FANG, L., ZHU, Q., SCHIPPER, J. H., LODDENKEMPER, C., KOSEL, F., BRINKMANN, V., ECKERT, K., HINDERSIN, S., HOLLAND, J. D., LEHR, S., KAHN, M., ZIEBOLD, U. & BIRCHMEIER, W. 2013. Wnt/beta-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours. EMBO J, 32, 1977-89.

13. HOLLAND, J. D., GYORFFY, B., VOGEL, R., ECKERT, K., VALENTI, G., FANG, L., LOHNEIS, P., ELEZKURTAJ, S., ZIEBOLD, U. & BIRCHMEIER, W. 2013. Combined Wnt/beta-catenin, Met, and CXCL12/CXCR4 signals characterize basal breast cancer and predict disease outcome. Cell Rep, 5, 1214-27.

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