助理教授 |医学院

陈浩,南方科技大学助理教授,博士生导师。近年来,主导和参与了表观遗传学修饰异常与代谢紊乱、信号传导通路调控表观遗传学修饰等一系列研究工作,并且鉴定了多种全新的表观遗传学修饰模式及详细阐明其在各类疾病发生中的分子机制。主要发现包括:1)鉴定出数个全新的RNA修饰酶,并阐明多种全新的RNA修饰的生物学功能,代表性工作包括:METTL4 (Cell Research, 2020; Cell Discovery, 2020), METTL5 (EMBO Reports, 2020; bioRxiv, 2020), METTL15 (JBC, 2020), ZCCHC4 (NCB, 2019), PCIF1(Molecular Cell, 2019), METTL3/14 (Nature, 2017),极大地拓展了整个领域对于新型表观遗传学修饰的认知;2)揭示糖尿病人中的糖代谢功能障碍促进肿瘤发生的表观遗传学机制(Nature,2018; Cell Research, 2019),首次发现“AMPK-14/3/3-TET2”调控轴为导致糖尿病人肿瘤高发的主要分子通路,引起相关领域的广泛关注,得到Nature Reviews Cancer, Nature Reviews Molecular Cell Biology等杂志的专文推荐;3)通过分析影响表观遗传核心蛋白稳定性的调节因子,揭示外界刺激如何信号传导通路调控表观遗传学建立及维持的新机制(PNAS,2012;MCB,2013)。

个人简介

研究领域

1. 疾病发生的表观遗传学机制;

2. 新型表观遗传学修饰的鉴定与功能研究。


学术成果 查看更多

1.Xing,M.#, Liu, Q.#, Mao, C., Zeng, H., Zhang, X., Zhao, S., Chen, L., Liu, M., Shen, B., Guo, X.,Ma,H.*, Chen, H.*,and Zhang, J.*. The 18S rRNA m6A methyltransferase regulates mouse embryonic stem cell differentiation. EMBO Reports. ( *co-corresponding author)

2.Chen, H.#, Gu, L.#, Orellana, E., Wang, Y., Guo, J., Liu, Q., Gregory, R., Xing, Y., Shi, Y. (2020). METTL4 is an m6Am methyltransferase that regulates RNA splicing. Cell Research. doi:10.1038 /s41422-019-0270-4 (#co-first author, F1000 recommended)

3.Wu, D.#, Hu, D.#, Chen, H.#, Shi, G.#, Fetahu, I. S., Wu, F., . . . Shi, Y. G. (2018). Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer. Nature. 559(7715), 637-641. (#co-first author)

4.Chen, H., Yu, D., Fang, R., Rabidou, K., Wu, D., Hu, D., . . Shi, Y. G. (2019). TET2 stabilization by 14-3-3 binding to the phosphorylated Serine 99 is deregulated by mutations in cancer. Cell Research. 29, 248–250. 

5.Chen, H., Shi, Z., Guo, J., Chang, K., Chen, Q., Yao, C., Haigis,M., Shi, Y. (2020). The human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for proper mitochondrial function. Journal of Biological Chemistry. jbc. RA119. 012127

6.Gu, L.#,Wang, L.#, Chen, H.#, Hong, J.#, Shen, Z., Dhall, A., Lao, T., . . . Wu, H., Shi, Y. (2020). CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila. Cell DIscovery (#co-first author)

7.Chen, H.#, Liu, Q.#, Yu, D., Natchiar, K., Zhou, C., Hsu, C.-h., Hsu, P.-H., Zhang, X., Klaholz, B., Gregory, R. and Shi, Y. (2020) METTL5, an 18S rRNA-specific m6A methyltransferase, modulates expression of stress response genes. bioRxiv. doi: https://doi.org/10.1101/2020.04.27.064162 (#co-first author)

8.Sendinc, E., Valle-Garcia, D., Dhall, A., Chen, H., Henriques, T., Navarrete-Perea, J., Sheng, W., Gygi, S., Adelman, K., Shi, Y.(2019). PCIF1 catalyzes m6Am mRNA methylation to regulate gene expression. Molecular Cell.

9.Ma, H., Wang, X., Cai, J., Dai, Q., Natchiar, S. K., Lv, R., . . Chen, H., . . He,C. (2019). N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation. Nature Chemical Biology. 15(1), 88.

10.Lee, Y., Chen, M., Lee, J., Zhang, J., Lin, S., Fu, T., Chen, H., Ishikawa, T., Chiang, S., Katon, J., .... Wei W., Pandolfi P.(2019). Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 364,6441

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