副教授 生物系 课题组网站
Andrew Hutchins 博士毕业于英国东安格利亚大学,曾长时间任职于新加坡基因组研究所和日本大阪大学的免疫学前沿研究中心。在来南方科技大学之前,任职于中国科学院广州生物医药与健康研究院,进行多能干细胞重编程的分子障碍和重编程途径的研究,长期从事干细胞、转座子研究,细胞命运调控和转换研究,在生物信息学、计算基因组学、诱导多能干细胞和表观遗传学领域做出了系统与创新性工作。对于多能干细胞的研究有着丰富的经验,近5年来以第一作者或者合作作者身份,在Nature Communications,Cell Stem Cell,Nature Cell Biology,Nucleic Acids Research,Stem Cells,Blood, Cell Research等知名国际期刊发表文章40多篇学术论文。
个人简介
Andrew Hutchins 博士毕业于英国东安格利亚大学,曾长时间任职于新加坡基因组研究所和日本大阪大学的免疫学前沿研究中心。在来南方科技大学之前,任职于中国科学院广州生物医药与健康研究院,进行多能干细胞重编程的分子障碍和重编程途径的研究,长期从事干细胞、转座子研究,细胞命运调控和转换研究,在生物信息学、计算基因组学、诱导多能干细胞和表观遗传学领域做出了系统与创新性工作。对于多能干细胞的研究有着丰富的经验,近5年来以第一作者或者合作作者身份,在Nature Communications,Cell Stem Cell,Nature Cell Biology,Nucleic Acids Research,Stem Cells,Blood, Cell Research等知名国际期刊发表文章40多篇学术论文。
研究领域
我们团队在hESCs 基础研究,hESCs 分化巨噬细胞,细胞重编程,先天性免疫细胞、转座子和细胞分化机制有着丰富的研究经验和研究成果,同时专注于下一代测序生物学数据的计算分析,以及基因组学、生物信息学分析等。
教学
2017春季学期 Bioinformatics and Genomics (博士、研究生课程)
2017春季学期 Scientific Writing and Communication (博士、研究生课程)
学术成果 查看更多
发表的论文著作 (Selected)
- Ma R*, Zhou X*, Zhai X*, Wang C, Hu R, Chen Y, Shi L, Fang X, Liao Y, Ma L, Jiang M, Wu J, Wang R, Chen J, Cao T, Du G, Zhao Y, Wu W, Chen H, Li S, Lian Q, Guo G#, Xiao J#, Hutchins AP#, Yuan P# (2024) Single-cell RNA sequencing reveals immune cell dysfunction in the peripheral blood of patients with highly aggressive gastric cancer. Cell Proliferation. e13591. *Co-first, #Co-corresponding.
- Fu X, Zhuang Q, Babarinde IA, Shi L, Ma G, Hu H, Li Y, Chen J, Xiao Z, Deng B, Sun L, Jauch R, Hutchins AP# (2023) Restricting epigenetic activity promotes the reprogramming of transformed cells to pluripotency in a line-specific manner. Cell Death Discovery. 9(1):245.
- Chang C, Ma G, Cheung E#, Hutchins AP#. (2022) A programmable system to methylate and demethylate N6-Methyladenosine (m6A) on specific RNA transcripts in mammalian cells. Journal of Biological Chemistry. 298(11):102525. #Co-corresponding.
- Yang Y*, Shi L*, Fu X, Ma G, Yang Z, Li Y, Zhou Y, Yuan L, Xiao Y, Zhong X, Yin P, Sun L, Zhang W, Babarinde IA, Wang Y, Zhao X, Hutchins AP#, Tong GQ#. (2022) Metabolic and epigenetic dysfunctions underlie the arrest of in vitro fertilized human embryos in a senescent-like state. PLoS Biology. 20(6):e3001682. *Co-first, #Co-corresponding.
- Babarinde IA#, Hutchins AP#. (2022) The effects of sequencing depth on the assembly of coding and noncoding transcripts in the human genome. BMC Genomics. 23(1):487. #Co-corresponding.
- Ma G, Babarinde IA, Zhou X, Hutchins AP. (2022) Transposable elements in pluripotent stem cells and human disease. Frontiers in Genetics. 13:902541. Invited Review
- Babarinde IA, Ma G, Li Y, Deng B, Luo Z, Liu H, Abdul M, Ward C, Chen M, Fu X, Shi L, Duttlinger M, He J, Sun L, Li W, Zhuang Q, Tong G, Frampton J, Cazier JB, Chen J, Jauch R, Esteban MA, Hutchins AP. (2021) Transposable element sequence fragments incorporated into coding and noncoding transcripts modulate the transcriptome of human pluripotent stem cells. Nucleic Acids Research. 49(16):9132-9153.
- Hutchins AP. (2021) Single cells and transposable element heterogeneity in stem cells and development. Cell Regeneration. 10(1): 23. Invited Review
- He J, Babarinde IA, Sun L, Xu S, Chen R, Shi J, Li Y, Ma G, Zhuang Q, Hutchins AP#, Chen J#. (2021) Identifying transposable element expression dynamics and heterogeneity during development at the single cell level with scTE. Nature Communications. 12:1456. #Co-corresponding.
- Sun L, Ma G, Fu X, Hutchins AP (2021) Chromatin and epigenetic rearrangements in embryonic stem cell fate transitions. Frontiers in Cell and Developmental Biology (Stem Cell Research Special Issue). 9:637309. Invited Review
- Ma G, Babarinde IA, Zhuang Q, Hutchins AP (2021) Unified Analysis of Multiple ChIP-Seq Datasets. Methods in Molecular Biology. 2198:451-465.
- Steffens S, Fu X, He F, Li Y, Babarinde IA, Hutchins AP (2020) DPre: Computational identification of differentiation bias and genes underlying cell type conversions. Bioinformatics. 36(5):1637-1639.
- Babarinde IA, Li Y, Hutchins AP (2019). Computational Methods for Mapping, Assembly and Quantification for Coding and Non-coding Transcripts. Computational and Structural Biotechnology Journal. 17: 628-637. Invited Review
- He J, Fu X, Zhang M, He F, Li W, Abdul M, Zhou J, Sun L, Chang C, Li Y, Liu H, Wu K, Babarinde IA, Zhuang Q, Loh YH, Chen J, Esteban MA, Hutchins AP. (2019). Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells. Nature Communications. 10(1):34.
- Zhuang Q*, Li W*, Benda C*, Huang Z, Ahmed T, Liu P, Guo X, Ibañez D, Luo Z, Zhang M, Abdul M, Yang Z, Yang J, Huang Y, Zhang H, Huang D, Zhou J, Zhong X, Zhu X, Fu X, Fan W, Liu Y, Xu Y, Ward C, Khan M, Kanwal S, Mirza B, Tortorella M, Tse HF, Chen J, Qin B, Bao X, Gao S, Hutchins AP#, Esteban MA#. (2018) NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming. Nature Cell Biology. 20(4):400-412. *Co-first, #Co-corresponding
- Li D*, Liu J*, Yang X*, Zhou C, Guo J, Wu C, Qin L, He J, Yu S, Liu H, Wang X, Wu F, Kuang J, Hutchins AP#, Chen J#, Pei D# (2017) Chromatin accessibility dynamics during iPSC reprogramming. Cell Stem Cell. 21(6):819-833. *Co-first, #Co-corresponding
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南科大生物系成立于2012年,在短短7年多时间里,吸引了一批海内外高尖端人才加盟,已初步建成了以资深教授领军,科研活跃和发展势头强劲的副教授为中坚力量,年轻助理教授为前锋的一支国际化高水平的教研序列队伍。生物系引进的教授序列全部具有博士学位,毕业于国际一流大学,在海外知名大学或研究机构从事过博士后研究,或在国际一流大学获得教职。其中的资深教授在加入南科大之前已经在境外著名高校或科研机构获得了终身教授的职位。此外,南方科技大学生物系还吸引了以年轻的博士、博士后组成的工程师团队辅助教学和科研工作的展开。教学与科研辅助人员逾300人。研究方向涵盖分子细胞生物学、神经生物学、植物生物学、系统生物学、结构生物学等领域,侧重生命科学前沿领域的基础研究以及与生命科学相关的应用基础研究,积极鼓励学科交叉。