Professer School of Medicine, Department of Medical Neuroscience
Xue-Jun Song, MD, PhD
Professor of Neurobiology and Medicine
Chair, Department of Medical Neuroscience
Director, SUSTech Center for Pain Medicine
Chair, Department of Perioperative Medicine, SUSTech Hospital
School of Medicine
Southern University of Science and Technology (SUSTech)
Shenzhen, China
Dr. Xue-Jun Song obtained his PhD in Neurobiology from Chinese Academy of Sciences Institute of Neuroscience and had his postdoctoral training at Yale University School of Medicine. Dr. Song was then serving as a faculty from young tenure-track to senior tenured in the University of Texas Medical Center and Parker University, respectively, for total eighteen years. Dr. Song was then served as a professor at Peking University Health Science Center Beijing and Director of Peking University Center for Pain Medicine. He also served as Vice Chair of Department of Anesthesiology and Director of Center for Anesthesiology and Pain Medicine at Peking University Cancer Hospital, Director of Jiangsu Province Key Laboratory of Anesthesiology and Vice Dean of School of Anesthesiology at Xuzhou Medical University. In the national and international academic societies, Dr. Song currently serves as committee members of the Scientific Program Committee, Task-Force for Pain Definition, and Membership Committee of the International Association for the Study of Pain (IASP), member of Science and Education Committee of American Academy of Pain Medicine (AAPM), Chair of Chinese Association for the Study of Pain (CASP) and China Chapter of IASP, Councilor of Chinese Neuroscience Society, Vice Chairs of Chinese Society for Pharmacology subcommittee Anesthesia-Pharmacology and Chinese Physiological Society subcommittee Translational Pain Research Committee, and Vice President of Shenzhen City Association for Pain Physicians, etc. Dr. Song is also serving as the Senior or Associate Editors for the Journal of Neurophysiology and Biochemistry, Pain Medicine, Pain, Neurobiology of Pain and PainReports as well as Executive Senior Editor and English Editor of the Chinese J Pain Medicine.
Dr. Song has been involving in basic medical research and clinical practice in the fields of neuroscience, pain medicine and anesthesiology. He has been a leading scientist in understanding the primary and secondary sensory neuron excitability, synaptic plasticity and the intracellular signaling transduction as well as their roles in neuropathic pain, cancer pain, and opiate actions particularly regarding the roles of WNT signaling and ephrinB-EphB receptor signaling in neuropathic and cancer pain and opiate actions. His research has been funded by the key national and international research grants and has resulted in several dozens of high-quality original research articles published in the peer-reviewed journals including Anesthesiology, Brain, Cancer Res, J Clin Invest, J Neurosci, Nat Neurosci, Pain, etc., as well as international invention patents. Many of his research outcomes were highlighted by major scientific organizations including American Physiological Society, American Association of Cancer Research, the key media like NBC, CBS, etc., and the scientific journals including Nature Review Drug Discovery, Nature Publishing Group, PainResForum, etc., and recognized by the prestigious national and international scientific awards. Dr. Song has received AAPM 2018 Robert Adison Award from AAPM, The Scott Haldeman Award and The Louis Sportelli NCMIC Award from WFC, Outstanding Young Scientist Award from National Natural Science Foundation of China, Advance Award of Science and Technology from Chinese Ministry of Education, Chinese Academy of Sciences, etc. Dr. Song has also made great contributions to the high education of pain medicine and has outstanding records, i.e., he started the first courses of Pain Medicine and Perioperative Medcine for the medical students at Peking University Health Science Center since 2014 and SUSTech Medical School (reported by China Health News, and IASP highlights), and that his student won the 2016 Rhodes Scholar, the first Chinese medical student who won the honor in the history of Rhodes Scholar.
Personal Profile
Xue-Jun Song, MD, PhD
Professor and Director, SUSTech Center for Pain Medicine
Southern University of Science and Technology (SUSTech) School of Medicine, Shenzhen
Dr. Xue-Jun Song obtained his MD (clinical medicine) from Xuzhou Medical University in 1986 and PhD in Neurobiology from Chinese Academy of Sciences Institute of Neuroscience and had his postdoctoral training at Yale University School of Medicine. Dr. Song was serving as a faculty from young tenure-track to senior tenured (full professor) in the University of Texas Medical Center and Parker University, respectively, for total eighteen years. Dr. Song then served as a professor at Peking University Health Science Center Beijing and Director of Peking University Center for Pain Medicine. He also served as Vice Chair of Department of Anesthesiology and Director of Center for Anesthesiology and Pain Medicine at Peking University Cancer Hospital, Director of Jiangsu Province Key Laboratory of Anesthesiology and Vice Dean of School of Anesthesiology at Xuzhou Medical University. In the national and international academic societies, Dr. Song currently serves as committee members of the Scientific Program Committee, Task-Force for Pain Definition, and Membership Committee of the International Association for the Study of Pain (IASP), member of Science and Education Committee of American Academy of Pain Medicine (AAPM), Chair of Chinese Association for the Study of Pain (CASP) and China Chapter of IASP, Councilor of Chinese Neuroscience Society, Vice Chairs of Chinese Society for Pharmacology subcommittee Anesthesia-Pharmacology and Chinese Physiological Society subcommittee Translational Pain Research Committee, and Vice President of Shenzhen City Association for Pain Physicians, etc. Dr. Song is also serving as the Senior/Section Editors for the Journal of Neurophysiology and Biochemistry and the journal Pain Medicine, and Associate Editors for the journals Neurobiology of Pain, PainReports, and PAIN (journals published by IASP or AAPM), as well as an Associate Chief-in-Editor of Chinese J Pain Medicine.
Dr. Song has been involving in basic medical research and clinical practice in the fields of neuroscience, pain medicine and anesthesiology. He has been a leading scientist in understanding the primary and secondary sensory neuron excitability, synaptic plasticity and the intracellular signaling transduction as well as their roles in neuropathic pain, cancer pain, and opiate actions particularly regarding the roles of WNT signaling and ephrinB-EphB receptor signaling in neuropathic and cancer pain and opiate actions. His research has been funded by the key national and international research grants from the United States, Australia, and China and resulted in several dozens of high-quality original research articles published in the peer-reviewed journals including Anesthesiology, Brain, Cancer Res, J Clin Invest, J Neurosci, Nat Neurosci, Pain, etc., as well as international invention patents. Many of his research outcomes were highlighted by major scientific organizations including American Physiological Society, American Association of Cancer Research, the key media like NBC, CBS, etc., and the scientific journals including Nature Review Drug Discovery, Nature Publishing Group, PainResForum, etc., and recognized by the prestigious national and international scientific awards. Dr. Song received AAPM 2018 Robert Adison Award from AAPM, The Scott Haldeman Award and The Louis Sportelli NCMIC Award from WFC, Outstanding Young Scientist Award from National Natural Science Foundation of China, Advance Award of Science and Technology from Chinese Ministry of Education, Chinese Academy of Sciences, etc. Dr. Song has also made great contributions to the high education of pain medicine and has outstanding records, i.e., he started the first pain medicine course for the medical students at Peking University Health Science Center since 2014 (reported by China Health News, and IASP highlights), and that his student won the 2016 Rhodes Scholar, the first Chinese medical student who won the honor in the history of Rhodes Scholar.
Research Interests
1. Sensory neuron excitability, synaptic plasticity, and intracellular signal transduction
2. Cellular and molecular mechanisms underlying chronic pain after nerve injury, cancer, or diabetes as well as opiate actions; new drug and technology research and development for chronic pain treatment
3. Neural mechanisms underlying general anesthesia, awakening, and consciousness
4. Empathy: neural circuits and application in the artificial intelligence
Professional Experience
2017— Professor, SUSTech Medical School; Director of SUSTech Center for Pain Medicine, SUSTech
2016—2018 Professor and Member of Medical School Planning Committee, SUSTech
2012—2017 Professor of Neurobiology and Pain Medicine, Neuroscience Research Institute and Department of Neurobiology; Professor of Oncology, Anesthesiology and Pain Medicine, Director of Center for Anesthesiology and Pain Medicine, Vice Chair of Department of Anesthesiology, Cancer Hospital; Director of Center for Pain Medicine and Vice Chair of its Academic Committee, Peking University Health Science Center and Peking University Cancer Hospital, Beijing
1999—2016 Senior Scientist and Assistant Professor (1999-2000), Associate Professor (2000-2003), and Full Professor (2004-2016) of Neurobiology and Pain Medicine, Member of Academic Advisory Committee, Associate Director of Parker Research Institute (Health Science) and Director of Section of Basic Science Research, Parker University, Dallas, Texas
1998—1999 Instructor and then Research Assistant Professor, The University of Texas Medical Center, Houston, Texas
1995—1998 Postdoctoral Fellow, Department of Anesthesiology and Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut
1986—1995 Resident, Instructor and Associate Professor, Department of Physiology and Department of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu Province
2007—2012 Adjunct Professor, Institute of Neuroscience and Department of Anesthesiology, The Fourth Military Medical University, Xi’an, Shan’xi
2005—2010 Distinguished Professor of Anesthesiology, Director of Jiangsu Province Key Lab of Anesthesiology, Vice Dean of School of Anesthesiology, and Funding Director of Department/Center for Pain Research and Management, Xuzhou Medical University, Xuzhou, Jiangsu Province.
Educational Background
1981-1986 MB/MD in Clinical Medicine, Xuzhou Medical University, Xuzhou, Jiangsu Province
1989-1992 MS in Clinical Medicine major in Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu Province
1992-1995 PhD in Neurobiology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai
Honors & Awards
2018 Robert Addison Award for the outstanding contribution to pain medicine and the international cooperation (to one scientist or physician per year worldwide), AAPM, USA
2015 The Louis Sportelli NCMIC Award, WFC Scientific Award-Class Second, Athens, Greece
2005 The Scott Haldeman Award, WFC Scientific Award-Class First, Sydney, Australia
2005 Outstanding Professorship Award, Parker University, USA
2005 Researcher of the Year, Activator International LTD, USA
2004 Award of Advancement of Science and Technology-Class First, Ministry of Education
1999 Award of Natural Science-Class Second, Chinese Academy of Sciences
1995 Outstanding Young Scientist Award, Chinese Academy of Sciences, Shanghai
1994 Presidential Award, Chinese Academy of Sciences
1993 ZhangXJ Foundation Research Award for National Young Scientists-Class Second, Chinese Physiological Society, Beijing
Selected representative publications in recent years
1. Song XJ*, Hu JJ. Neurobiological basis of emergence from anesthesia. Trends in Neurosciences 2024 May;47(5):355-366. doi: 10.1016/j.tins.2024.02.006. Epub 2024 Mar 14. PMID: 38490858.
2. Li LH, Yao HY, Mo RF, Xu LH, Chen P, Chen YC, Hu JJ, Xie W, Song XJ*. Blocking proteinase-activated receptor 2 signaling relieves pain, suppresses nerve sprouting, improves tissue repair, and enhances analgesic effect of B vitamins in rats with Achilles tendon injury. Pain 2024 Apr 9; Epub ahead of print.
3. Hu JJ, Liu YX, Yao HY, Cao BX, Liao HB, Yang RD, Chen P, Song XJ*. Emergence of consciousness from anesthesia through ubiquitin degradation of KCC2 in the ventral posteromedial nucleus of the thalamus. Nature Neuroscience 2023 May;26(5):751-764.
4. Ma P, Mo R, Liao H, Qiu C, Wu G, Yang C, Zhang Y, Zhao Y, Song XJ*. Gut microbiota depletion by antibiotics ameliorates somatic neuropathic pain induced by nerve injury, chemotherapy, and diabetes in mice. Journal of Neuroinflammation 2022 Jun 28;19(1):169.
5. Deng X, Ma P, Wu M, Liao H, Song XJ*. Role of matrix metalloproteinases in myelin abnormalities and mechanical allodynia in rodents with diabetic neuropathy. Aging and Disease 2021 Oct 1;12(7):1808-1820.
6. Wu MZ, Li ZH, Liang L, Ma PC, Cui D, Chen P, Wu GH, Song XJ*. Wnt signaling contributes to withdrawal symptoms from opioid receptor activation induced by morphine exposure or chronic inflammation. Pain 2020 Mar;161(3):532-544.
7. Ma PC, Chen P, Zhou ZL, Wu MZ, Song XJ*. Activation of EphB receptors contributes to primary sensory neuron excitability by facilitating Ca2+ influx directly or through Src kinase-mediated N-methyl-D-aspartate receptor phosphorylation. Pain 2020 Feb 27. PMID: 32149862.
8. Xu N, Wu MZ, Deng XT, Ma PC, Li ZH, Liang L, Song XJ*. Inhibition of YAP/TAZ Activity in Spinal Cord Suppresses Neuropathic Pain. The Journal of Neuroscience 2016; 36(39):10128-40.
9. Liu S, Liu YP, Huang ZJ, Zhang YK, Song AA, Ma PC, Song XJ*. Wnt/Ryk signaling contributes to neuropathic pain by regulating sensory neuron excitability and spinal synaptic plasticity in rats. Pain 2015; 156(12):2572-84.
10. Liu S, Liu YP, Song WB, Song XJ*. EphrinB-EphB receptor signaling contributes to bone cancer pain via Toll-like receptor and proinflammatory cytokines in rat spinal cord. Pain 2013;154(12):2823-35.
11. Zhang YK, Huang ZJ, Liu S, Liu YP, Song AA, Song XJ*. WNT signaling underlies the pathogenesis of neuropathic pain in rodents. Journal of Clinical Investigation (JCI) 2013; 123(5):2268-86.
12. Huang ZJ, Li HC, Cowan AA, Zhang YK, Song XJ*. Chronic compression or acute dissociation of dorsal root ganglion induces cAMP-dependent neuronal hyperexcitability through activation of PAR2. Pain 2012; 153:1426-1437.
13. Wu XF, Liu WT, Liu YP, Huang ZJ, Zhang YK, Song XJ*. Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord. Pain 2011;152:2605-2613.
14. Liu S, Liu WT, Liu YP, Dong HL, Henkemeyer M, Song XJ*. Blocking EphB1 receptor forward signaling in spinal cord relieves bone cancer pain and rescues analgesic effect of morphine treatment. Cancer Research 2011;71(13):4392-402.
15. Liu WT, Han Y, Liu YP, Song AA, Barnes B, Song XJ*. Spinal matrix metalloproteinase-9 contributes to physical dependence on morphine in mice. The Journal of Neuroscience 2010; 30: 7613-7623.
Research
1. Sensory and recognition neuroscience;
2. Consciousness and Empathy: molecular mechanisms and neural circuits and application in the artificial intelligence;
3. Cellular and molecular mechanisms underlying chronic pain after nerve injury, cancer, or diabetes as well as opiate actions; new drug and technology research and development for chronic pain treatment.
Teaching
Teaching undergraduate and graduate students in medical schools in Physiology, Neurobiology, Neuroscience Research Methods, Neuropharmacology, AnesthesioPhysiology, Pain Medicine, and Perioperative Medicine, for over three decades.
Publications Read More
Selected recent publications
1. Song XJ*, Hu JJ. Neurobiological basis of emergence from anesthesia. Trends in Neurosciences 2024 May;47(5):355-366. doi: 10.1016/j.tins.2024.02.006. Epub 2024 Mar 14. PMID: 38490858.
2. Li LH, Yao HY, Mo RF, Xu LH, Chen P, Chen YC, Hu JJ, Xie W, Song XJ*. Blocking proteinase-activated receptor 2 signaling relieves pain, suppresses nerve sprouting, improves tissue repair, and enhances analgesic effect of B vitamins in rats with Achilles tendon injury. Pain 2024 Apr 9; Epub ahead of print.
3. Hu JJ, Liu YX, Yao HY, Cao BX, Liao HB, Yang RD, Chen P, Song XJ*. Emergence of consciousness from anesthesia through ubiquitin degradation of KCC2 in the ventral posteromedial nucleus of the thalamus. Nature Neuroscience 2023 May;26(5):751-764.
4. Ma P, Mo R, Liao H, Qiu C, Wu G, Yang C, Zhang Y, Zhao Y, Song XJ*. Gut microbiota depletion by antibiotics ameliorates somatic neuropathic pain induced by nerve injury, chemotherapy, and diabetes in mice. Journal of Neuroinflammation 2022 Jun 28;19(1):169.
5. Deng X, Ma P, Wu M, Liao H, Song XJ*. Role of matrix metalloproteinases in myelin abnormalities and mechanical allodynia in rodents with diabetic neuropathy. Aging and Disease 2021 Oct 1;12(7):1808-1820.
6. Wu MZ, Li ZH, Liang L, Ma PC, Cui D, Chen P, Wu GH, Song XJ*. Wnt signaling contributes to withdrawal symptoms from opioid receptor activation induced by morphine exposure or chronic inflammation. Pain 2020 Mar;161(3):532-544.
7. Ma PC, Chen P, Zhou ZL, Wu MZ, Song XJ*. Activation of EphB receptors contributes to primary sensory neuron excitability by facilitating Ca2+ influx directly or through Src kinase-mediated N-methyl-D-aspartate receptor phosphorylation. Pain 2020 Feb 27. PMID: 32149862.
8. Xu N, Wu MZ, Deng XT, Ma PC, Li ZH, Liang L, Song XJ*. Inhibition of YAP/TAZ Activity in Spinal Cord Suppresses Neuropathic Pain. The Journal of Neuroscience 2016; 36(39):10128-40.
9. Liu S, Liu YP, Huang ZJ, Zhang YK, Song AA, Ma PC, Song XJ*. Wnt/Ryk signaling contributes to neuropathic pain by regulating sensory neuron excitability and spinal synaptic plasticity in rats. Pain 2015; 156(12):2572-84.
10. Liu S, Liu YP, Song WB, Song XJ*. EphrinB-EphB receptor signaling contributes to bone cancer pain via Toll-like receptor and proinflammatory cytokines in rat spinal cord. Pain 2013;154(12):2823-35.
11. Zhang YK, Huang ZJ, Liu S, Liu YP, Song AA, Song XJ*. WNT signaling underlies the pathogenesis of neuropathic pain in rodents. Journal of Clinical Investigation (JCI) 2013; 123(5):2268-86.
12. Huang ZJ, Li HC, Cowan AA, Zhang YK, Song XJ*. Chronic compression or acute dissociation of dorsal root ganglion induces cAMP-dependent neuronal hyperexcitability through activation of PAR2. Pain 2012; 153:1426-1437.
13. Wu XF, Liu WT, Liu YP, Huang ZJ, Zhang YK, Song XJ*. Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord. Pain 2011;152:2605-2613.
14. Liu S, Liu WT, Liu YP, Dong HL, Henkemeyer M, Song XJ*. Blocking EphB1 receptor forward signaling in spinal cord relieves bone cancer pain and rescues analgesic effect of morphine treatment. Cancer Research 2011;71(13):4392-402.
15. Liu WT, Han Y, Liu YP, Song AA, Barnes B, Song XJ*. Spinal matrix metalloproteinase-9 contributes to physical dependence on morphine in mice. The Journal of Neuroscience 2010; 30: 7613-7623.
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【申请人主要研究领域和学术背景要求】
神经生物学、生物化学、神经药理学、细胞生物学、神经免疫学、生物医学工程、基础和临床医学等学科背景。
(一)博士后Postdoctoral Researchers
【基本要求】
已获得相关专业全日制博士学位,且获得博士学位时间一般不超过2年。具有扎实的专业知识、研究技能和独立开展科学研究的能力,具有优秀的科学研究训练和实践记录。
热爱科学并对神经科学研究充满兴趣,有具有良好的团队合作精神。
具有良好的英语写作能力和中英文交流能力。
【岗位待遇】
(1)博士后聘用期两年,年薪33万元起,含广东省生活补助15万元及深圳市生活补助6万元,并按深圳市有关规定参加社会保险及住房公积金。博士后福利费参照学校教职工标准发放。
(2)特别优秀候选人可以申请校长卓越博士后,年薪可达50万元以上(含广东省及深圳市补助)。
(3)在站期间,可依托学校申请深圳市公租房,未依托学校使用深圳市公租房的博士后,可享受两年税前2800元/月的住房补贴。
(4)拥有优良的工作环境和境内外合作交流机会,博士后在站期间享受两年共计2.5万学术交流经费资助。
(5)课题组协助符合条件的博士后申请“广东省海外青年博士后引进项目”。即在世界排名前200名的高校(不含境内,排名以上一年度泰晤士、USNEWS、QS和上海交通大学的世界大学排行榜为准)获得博士学位,在广东省博士后设站单位从事博士后研究,并承诺在站2年以上的博士后,申请成功后省财政给予每名进站博士后资助60万元生活补贴(与广东省每年15万生活补助不同时享受,与深圳市每年6万元生活补助同时享受情况以深圳市规定为准);对获得本项目资助,出站后与广东省用人单位签订工作协议或劳动合同,并承诺连续在粤工作3年以上的博士后,省财政给予每人40万元住房补贴。
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(二)科研助理、副研究员
【招聘要求】
具有生物医药等生命科学相关专业硕士或博士学位。熟练掌握生物医药学实验技术,包括神经电生理、药理、分子生物学、免疫组织化学等技术。
热爱科研工作,责任心强,工作认真有效率,有出色团队合作精神,可协助或者独立进行科学研究,服从安排、完成或者协助完成实验室其它工作。
英语水平良好。
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【招聘要求】
本科及以上学历。
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具备良好的中英文写作交流能力,熟练掌握日常办公软件。
【岗位待遇】
基本薪资根据学历和经历面议,五险一金,各项福利,补贴等参照学校标准缴纳、发放。
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