• Journal Papers
  • Invention Patent
  • Authored Books
    1. Zhang X, Shi S, Su Y, Yang X, He S, Wu J, Zhang J, Rao, F.*. Suramin and NF449 are IP5K inhibitors that disrupt IP6-mediated regulation of cullin RING ligase and sensitize cancer cells to MLN4924/Pevonedistat. J. Biol. Chem. 2020 295,10281-10292.
    2. Lin H. #, Zhang X. #, Liu L.#, Fu QY., Zang CL., Ding Y., Xu ZX., He SN., Yang XL., Wei XY., Mao HB., Cui YS, Wei Yi., Zhou CZ., Du LL., Huang N., Zheng N., Wang T.*, and Rao F.*. Molecular basis of metabolite-dependent Cullin RING ligase deneddylation by the COP9 Siganalosome. Proc. Natl. Acad. Sci. USA. 2020 117, 4117-24.(F1000 recommendation) (Commentary)
    3. Zhang X, Rao F.*. Are inositol polyphosphates the missing link in dynamic Cullin RING ligase regulation by the COP9 Signalosome? Biomolecules. "ZOMES" Special Issue: 2019, 9, 349.
    4. 魏文毅*、孙毅*、曹诚、常智杰、陈策实、陈佺、程金科、冯仁田、高大明、胡荣贵、贾立军、姜天霞、金建平、李汇华、李卫、刘翠华、饶枫、商瑜、宋质银、万勇、王平、王占新、吴缅、吴乔、谢旗、谢松波、谢志平、徐平、许执恒、杨波、阳成伟、应美丹、张宏冰、张令强、赵永超、周军、朱军、王琳芳、张宏、王琛、邱小波*. 类泛素蛋白及其中文命名(Ubiquitin-like Proteins and their Chinese Nomenclatures). 科学通报. 2018, 63(25):2564-2569.
    5. Fu C., Tyagi R., Chin AC., Rojas T., Li RJ., Guha P., Bernstein IA., Rao F., Xu R., Cha JY., Xu J., Snowman AM., Semenza GL., Snyder SH. Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α [J]. Circ. Res. 2018 Feb 2, 122(3):457-472.
    6. Scherer PC., Zaccor NW., Neumann NM., Vasavda C., Barrow R., Ewald AJ., Rao F., Sumner CJ., Snyder SH. TRPV1 is a physiological regulator of μ-opioid receptors[J]. Proc. Natl. Acad. Sci. USA. 2017 Dec 19, 114(51):13561-13566.
    7. Scherer PC.#, Ding Y.#, Liu Z., Xu J., Mao H., Barrow JC., Wei N., Zheng N., Snyder SH*Rao F.*. Inositol hexakisphosphate(IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function. Proc. Natl. Acad. Sci. USA2016, 113, 3503-8.
    8. Rao F.#Xu J.#, Fu C.#, Cha JY., Xu R., Gadalla MM., Wu M., Fiedler D., Barrow JC., Snyder SH.*. Inositol pyrophosphates promote cancer growth and metastasis by antagonizing the tumor suppressor LKB1. Proc. Natl. Acad. Sci. USA2015 112, 1773-8. (Highlighted by Chemistry & Biology)
    9. Rao F.#Xu J.#, Kahn AB., Cha J., Xu R. Tyagi R., Dang Y., Chakraborty A., Snyder SH. Inositol hexakisphosphate kinase-1 mediates assembly/ disassembly of the CRL4-Signalosome complex to regulate DNA repair and cell death. Proc. Natl. Acad. Sci. USA2014, 111, 16005-16010.
    10. Rao F., Cha J., Xu J., Xu R., Vandiver MS., Tokhunt RT., Wu M., Fiedler D., Barrow J., Snyder SH. Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2. Mol. Cell. 2014, 54, 119-32.
    11. Tan E.#Rao F.#, Pasunooti S., Pham TH., Soehano I., Turner MS., Liew CW., Lescar J., Pervushin K., Liang Z-X.  Solution structure of the PAS domain of a thermophilic YybT homolog reveals a potential ligand-binding site. J. Biol. Chem. 2013, 288:11949-59.
    12. Xu R., Sen N., Paul BD., Rao F., Vandiver MS., Snyder SH. Inositol phosphate multikinase catalyzes the acetylation of p53 by p300, thereby functioning as a p53 transcriptional co-activator. Sci. Signal. 2013, 6, ra22: 1-10.
    13. Vandiver MS., Paul BD., Xu R., Karuppagounder S., Rao F., Snowman AM., Ko HS., Li YI., Sen N., Dawson VL., Dawson TM., Snyder SH. Sulfhydration mediates neuroprotective actions of Parkin. Nat. Commun. 2013, 4:1626.
    14. Xu R, Paul BD, Smith DR, Tyagi R, Rao F., Khan AB., Blech DJ., Vandiver MS., Harraz MM., Guha P., Ahmed I., Sen N., Gallagher M., Snyder SH. Inositol polyphosphate multikinase is a transcriptional coactivator required for immediate early gene induction. Proc. Natl. Acad. Sci. USA. 2013, 6, 110, 16181-.
    15. Cha J., Xu J., Paul BD., Rao F., Ho G., Snyder SH. Dexras1 Mediates adipogenesis and diet-induced obesity. Proc. Natl. Acad. Sci. USA. 2013, 110, 20575-.
    16. Rao, F., Wang T., Li M., Li Z., Hong N., Zhao H., Yan Y., Lu W., Chen T., Wang W., Lim M., Yuan Y., Liu L., Zeng L., Wei Q., Guan G., Li C., Hong Y. Medaka tertproduces multiple variants with differential expression during differentiation in vitro and in vivo Int. J. Biol. Sci2011, 7(4):426-439.
    17. Rao, F., Ji, Q., Soehano I., Liang Z-X. Unusual Heme-Binding PAS Domain from YybT Family Proteins. J. Bacteriol. 2011, 193:1543-1551.
    18. Rao, F.,See, RY., Zhang, D., Toh, DC., Liang Z-X*. YybT is a signaling protein that contains a cyclic-di-nucleotide phosphodiesterase domain and a GGDEF domain with ATPase activity. J. Biol. Chem. 2010, 285:473-82.
    19. Rao, F.*, Qi, Y., Murugan, E., Pasunooti, S., Ji, Q.. 2’,3’-cAMP hydrolysis by metal-dependent phosphodiesterases containing DHH, EAL, and HD domains is non-specific: implications for PDE screening. Biochem. Biophys. Res. Commun. 2010, 398:500-505.
    20. Rao, F., Pasunooti S., Ng Y., Zhuo W., Lim L., Liu AW., Liang Z-X. Enzymatic synthesis of c-di-GMP using a thermophilic diguanylate cyclase. Anal. Biochem. 2009, 389:138-42.
    21. Rao F., Qi Y., Chong HS., Kotaka M., Li B., Lescar J., Tang K., Liang Z-X. The functional role of a conserved loop in EAL domain-based c-di-GMP specific phosphodiesterase. J. Bacteriol. 2009, 191:4722-31. (Commentary: 191:4697-700).
    22. Rao F., Yang Y., Qi Y., Liang Z-X. Catalytic mechanism of C-di-GMP specific phosphodiesterase: a study of the EAL domain containing protein RocR from Psudomonas aeruginosa. J. Bacteriol. 2008, 190:3622-31. (F1000  recommendation)
    23. Chia WS., Chia, XD., Rao F., Bar-Nun S., Geifman S. ATP binding to p97/VCP regulates selective recruitment of adaptors to its proximal N-domain. PLOS ONE. 2012, 7: e50490.
    24. Chen M.W., Kotaka M., Vonrhein C., Bricogne G., Rao F., Chuah M.L., Svergun D., Schneider G., Liang Z-X. and Lescar J. Structural insights into the regulatory mechanism of the response regulator RocR from Pseudomonas aeruginosa in cyclic di-GMP signaling. J. Bacteriol. 2012, 194:4837-4846. (Front cover).
    25. Qi Y., Rao F., Luo Z., Liang Z- X. A flavin cofactor-binding PAS domain regulates C-di-GMP synthesis in AxDGC2 from Acetobacter xylinumBiochemistry. 2009, 48:10275-85.
    26. Kotaka M.*., Dutta S., Lee H.C., Lim M., Wong Y., Rao F., Mitchell E.P., Liang Z-X, Lescar JX. Expression, purification and preliminary crystallographic analysis of Pseudomonas aeruginosaRocR protein. Acta. Crystallogr. F. 2009, 65: 1035-1038.
    27. Murugan E., Kong R., Sun H., Rao F., Liang, Z-X. Expression, purification and characterization of acyl carrier protein phosphodiesterase from Pseudomonas aeruginosaProtein Expres. Purif. 2010, 71:132-138.

    (*= Corresponding Author; #=Co-first Author


  1. Liang, Z-X., Rao, F. Diguanylate cyclase method of producing the same and its use in the manufacture of cyclic-di-GMP and analogues thereof. 2014-10-14, US Patent No:  8,859,237.  
  1. Rao F.*,  Lin H, Su Y.. Cullin RING ligase regulation by the COP9 Signalosome: Structural Mechanisms and New Physiologic Players. Adv. Exp. Med. Biol. 2020, 1217, 47-60. (Invited Chapter, book “Cullin RING Ligases and Neddylation”).

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